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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-6-16
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pubmed:abstractText |
Transforming growth factor-beta 1 (TGF-beta 1) is the strongest chemoattractant yet described for human neutrophils. It activates neither phospholipase C nor phospholipase D. It does not induce rises in intracellular calcium, degranulation, or superoxide production. The signaling pathways utilized by TGF-beta 1 are largely unknown. This report demonstrates that TGF-beta 1 activates p38 MAP kinase. The kinase inhibitor SB203580 blocks the chemotactic responses as well as actin polymerization induced by TGF-beta 1. Potential cellular targets of the p38 MAP kinase pathway which could mediate these function are discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP-kinase-activated kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
246
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9600067-Actins,
pubmed-meshheading:9600067-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9600067-Chemotaxis, Leukocyte,
pubmed-meshheading:9600067-Enzyme Activation,
pubmed-meshheading:9600067-Enzyme Inhibitors,
pubmed-meshheading:9600067-Humans,
pubmed-meshheading:9600067-Imidazoles,
pubmed-meshheading:9600067-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9600067-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9600067-Neutrophils,
pubmed-meshheading:9600067-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9600067-Pyridines,
pubmed-meshheading:9600067-Signal Transduction,
pubmed-meshheading:9600067-Substrate Specificity,
pubmed-meshheading:9600067-Transforming Growth Factor beta,
pubmed-meshheading:9600067-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
1998
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pubmed:articleTitle |
The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophils.
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pubmed:affiliation |
Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA. mohann@erols.com
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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