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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5367
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pubmed:dateCreated |
1998-6-12
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pubmed:abstractText |
The factors that contribute to allergic asthma are unclear but the resulting condition is considered a consequence of a type-2 T helper (TH2) cell response. In a model of pulmonary allergic inflammation, mice that lacked gammadelta T cells had decreases in specific immunoglobulin E (IgE) and IgG1 and pulmonary interleukin-5 (IL-5) release as well as in eosinophil and T cell infiltration compared with wild-type mice. These responses were restored by administration of IL-4 to gammadelta T cell-deficient mice during the primary immunization. Thus, gammadelta T cells are essential for inducing IL-4-dependent IgE and IgG1 responses and for TH2-mediated airway inflammation to peptidic antigens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1265-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9596580-Animals,
pubmed-meshheading:9596580-Asthma,
pubmed-meshheading:9596580-Bronchi,
pubmed-meshheading:9596580-Bronchial Hyperreactivity,
pubmed-meshheading:9596580-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:9596580-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9596580-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9596580-Crosses, Genetic,
pubmed-meshheading:9596580-Eosinophils,
pubmed-meshheading:9596580-Female,
pubmed-meshheading:9596580-Immunization,
pubmed-meshheading:9596580-Immunoglobulin E,
pubmed-meshheading:9596580-Immunoglobulin G,
pubmed-meshheading:9596580-Interferon-gamma,
pubmed-meshheading:9596580-Interleukin-4,
pubmed-meshheading:9596580-Interleukin-5,
pubmed-meshheading:9596580-Lung,
pubmed-meshheading:9596580-Male,
pubmed-meshheading:9596580-Mice,
pubmed-meshheading:9596580-Mice, Inbred BALB C,
pubmed-meshheading:9596580-Ovalbumin,
pubmed-meshheading:9596580-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:9596580-T-Lymphocyte Subsets,
pubmed-meshheading:9596580-Th2 Cells
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pubmed:year |
1998
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pubmed:articleTitle |
Requirement for gammadelta T cells in allergic airway inflammation.
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pubmed:affiliation |
Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur/INSERM U485, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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