Linked Life Data

9596341

Source:http://linkedlifedata.com/resource/pubmed/id/9596341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-7-14
pubmed:abstractText
Recent evidence suggests disturbances of serotonin synthesis affecting the dentato-thalamo-cortical pathway in autistic boys. We studied possible effects of such disturbances on brain activations for language in autistic adults. Four autistic and five normal men were studied while listening to, repeating, and generating sentences, using [15(O)]-water positron emission tomography (PET). Activation in the right dentate nucleus and in the left frontal area 46 was reduced during verbal auditory and expressive language and enhanced during motor speech functions in the autism as compared to the control group. The thalamus showed group differences concordant with area 46 for expressive language. The results may indicate atypical functional specialization of the dentato-thalamo-cortical pathway and are compatible with a model of region-specific biochemical disturbances in the developing autistic brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
245
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography.
pubmed:affiliation
Department of Pediatrics at Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201-2196, USA. rmueller@pet.wayne.edu
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't