Linked Life Data

9593931

Source:http://linkedlifedata.com/resource/pubmed/id/9593931

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-7-7
pubmed:abstractText
The neuroprotective effects of lowering body temperature have been well documented in various models of neuronal injury. The present study investigated the effects a lower ambient or core body temperature would have on damage to striatal dopamine (DA) neurons produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice received systemic MPTP treatment at two different temperatures, 4 degrees C and 22 degrees C. MPTP-treated mice maintained at 4 degrees C demonstrated (1) a greater hypothermic response, (2) a significant reduction in striatal DA content and tyrosine hydroxylase (TH) activity, and (3) significantly greater striatal 1-methyl-4-phenylpyridinium (MPP+) levels, as compared to mice dosed with MPTP at room temperature. Parallel studies with methamphetamine (METH) were conducted since temperature appears to play a pivotal role in the mediation of damage to DA neurons by this CNS stimulant in rodents. As previously reported, METH-induced hyperthermia and the subsequent loss of striatal DA content were attenuated in animals dosed at 4 degrees C. We also evaluated the effects a hypothermic state induced by pharmacological agents would have on striatal neurochemistry and MPP+ levels following MPTP treatment. Concurrent administration of MK-801 or 8-OHDPAT increased the striatal MPP+ levels following MPTP treatment. However, only 8-OHDPAT potentiated the MPTP-induced decrements of striatal DA content and TH activity; MK-801 did not affect MPTP decreases in these striatal markers of dopaminergic damage. Altogether, these findings indicate that temperature has a profound effect on striatal MPP+ levels and MPTP-induced damage to DA neurons in mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
790
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:9593931-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, pubmed-meshheading:9593931-1-Methyl-4-phenylpyridinium, pubmed-meshheading:9593931-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:9593931-Animals, pubmed-meshheading:9593931-Body Temperature, pubmed-meshheading:9593931-Corpus Striatum, pubmed-meshheading:9593931-Dizocilpine Maleate, pubmed-meshheading:9593931-Dopamine, pubmed-meshheading:9593931-Dopamine Agents, pubmed-meshheading:9593931-Excitatory Amino Acid Antagonists, pubmed-meshheading:9593931-MPTP Poisoning, pubmed-meshheading:9593931-Methamphetamine, pubmed-meshheading:9593931-Mice, pubmed-meshheading:9593931-Nerve Degeneration, pubmed-meshheading:9593931-Neurons, pubmed-meshheading:9593931-Neurotoxins, pubmed-meshheading:9593931-Serotonin Receptor Agonists, pubmed-meshheading:9593931-Tyrosine 3-Monooxygenase
pubmed:year
1998
pubmed:articleTitle
Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice.
pubmed:affiliation
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.