Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-7-20
|
| pubmed:abstractText |
Ginseng root, a traditional oriental medicine, contains more than a dozen biologically active saponins called ginsenosides, including one present in only trace amounts called ginsenoside-Rf (Rf). Previously, we showed that Rf inhibits Ca2+ channels in mammalian sensory neurons through a mechanism requiring G-proteins, whereas a variety of other ginsenosides were relatively ineffective. Since inhibition of Ca2+ channels in sensory neurons contributes to antinociception by opioids, we tested for analgesic actions of Rf. We find dose-dependent antinociception by systemic administration of Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED50 was 56+/-9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED50 was 129+/-32 mg/kg. Rf failed to affect nociception measured in three assays of acute pain: the acute phase of the formalin test, and the thermal (49 degrees C) tail-flick and increasing-temperature (3 degrees C/min) hot-plate tests. The simplest explanation is that Rf inhibits tonic pain without affecting acute pain, but other possibilities exist. Seeking a cellular explanation for the effect, we tested whether Rf suppresses Ca2+ channels on identified nociceptors. Inhibition was seen on large, but not small, nociceptors. This is inconsistent with a selective effect on tonic pain, so it seems unlikely that Ca2+ channel inhibition on primary sensory neurons can fully explain the behavioral antinociception we have demonstrated for Rf.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Formaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Ginsenosides,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/ginsenoside Rf
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V.
|
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
792
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
218-28
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9593902-Abdominal Muscles,
pubmed-meshheading:9593902-Analgesics,
pubmed-meshheading:9593902-Animals,
pubmed-meshheading:9593902-Behavior, Animal,
pubmed-meshheading:9593902-Body Temperature,
pubmed-meshheading:9593902-Calcium Channel Blockers,
pubmed-meshheading:9593902-Calcium Channels,
pubmed-meshheading:9593902-Dose-Response Relationship, Drug,
pubmed-meshheading:9593902-Formaldehyde,
pubmed-meshheading:9593902-Ginsenosides,
pubmed-meshheading:9593902-Hot Temperature,
pubmed-meshheading:9593902-Locomotion,
pubmed-meshheading:9593902-Mice,
pubmed-meshheading:9593902-Neurons, Afferent,
pubmed-meshheading:9593902-Nociceptors,
pubmed-meshheading:9593902-Pain,
pubmed-meshheading:9593902-Panax,
pubmed-meshheading:9593902-Patch-Clamp Techniques,
pubmed-meshheading:9593902-Plants, Medicinal,
pubmed-meshheading:9593902-Saponins,
pubmed-meshheading:9593902-Tail
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice.
|
| pubmed:affiliation |
Dept. of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA. jmogil@s.psych.uiuc.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|