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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1998-7-1
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pubmed:abstractText |
GATA transcription factors represent a family of highly conserved zinc finger proteins with tissue-specific expression patterns. Previous studies have shown that GATA-6 is expressed in vascular smooth muscle cells (VSMCs) and rapidly down-regulated when VSMCs are induced to proliferate. Here we investigated whether the GATA-6 transcription factor can modulate cellular proliferation. Transient transfection with a GATA-6 expression vector inhibited S-phase entry in VSMCs and in mouse embryonic fibroblasts (MEFs) lacking both p53 alleles. The GATA-6-induced growth arrest correlated with a marked increase in the expression of the general cyclin-dependent kinase (Cdk) inhibitor p21. In contrast to p53-deficient MEFs and VSMCs, MEFs null for both p21 alleles were refractory to the GATA-6-induced growth inhibition. These data demonstrate that elevated GATA-6 expression can promote the quiescent phenotype in VSMCs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GATA6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gata6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13713-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9593712-Animals,
pubmed-meshheading:9593712-Base Sequence,
pubmed-meshheading:9593712-Cell Differentiation,
pubmed-meshheading:9593712-Cells, Cultured,
pubmed-meshheading:9593712-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:9593712-Cyclins,
pubmed-meshheading:9593712-DNA,
pubmed-meshheading:9593712-DNA Probes,
pubmed-meshheading:9593712-DNA Replication,
pubmed-meshheading:9593712-DNA-Binding Proteins,
pubmed-meshheading:9593712-G1 Phase,
pubmed-meshheading:9593712-GATA6 Transcription Factor,
pubmed-meshheading:9593712-Humans,
pubmed-meshheading:9593712-Mice,
pubmed-meshheading:9593712-Mice, Knockout,
pubmed-meshheading:9593712-Muscle, Smooth, Vascular,
pubmed-meshheading:9593712-Protein Binding,
pubmed-meshheading:9593712-Sequence Deletion,
pubmed-meshheading:9593712-Transcription Factors,
pubmed-meshheading:9593712-Tumor Suppressor Protein p53,
pubmed-meshheading:9593712-Zinc Fingers
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pubmed:year |
1998
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pubmed:articleTitle |
GATA-6 induces p21(Cip1) expression and G1 cell cycle arrest.
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pubmed:affiliation |
Program in Cell, Molecular, and Developmental Biology, Tufts University, Sackler School of Biomedical Studies, Boston, Massachusetts 02111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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