| pubmed-article:9593635 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C2330894 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0598528 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0205179 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0070317 | lld:lifeskim |
| pubmed-article:9593635 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9593635 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9593635 | pubmed:dateCreated | 1998-7-31 | lld:pubmed |
| pubmed-article:9593635 | pubmed:abstractText | Advanced glycation endproducts have been implicated in a number of diabetic and aging changes. Some of these effects occur in part through induction of cytokines such as platelet-derived growth factor (PDGF), which is expressed by the retinal pigment epithelium (RPE). In this study, cultures of RPE were evaluated for PDGF expression after treatment with pentosidine, a well characterized advanced glycation endproduct. Northern analysis provided evidence for the increased expression of a 3.7 kb PDGF-B transcript over unstimulated controls in the established ARPE-19 cell line. Western analysis demonstrated increased PDGF-BB protein in conditioned medium compared to controls of ARPE-19 cells. In addition, two different early passage cultures of RPE showed increased PDGF-BB protein after pentosidine treatment compared to unstimulated controls. The enhanced production of PDGF-BB could play a role in the maintenance of the RPE-Bruch's membrane complex and influence changes associated with diabetes and aging. | lld:pubmed |
| pubmed-article:9593635 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9593635 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9593635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9593635 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9593635 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9593635 | pubmed:issn | 0014-4835 | lld:pubmed |
| pubmed-article:9593635 | pubmed:author | pubmed-author:ReiserK MKM | lld:pubmed |
| pubmed-article:9593635 | pubmed:author | pubmed-author:MatsunagaHH | lld:pubmed |
| pubmed-article:9593635 | pubmed:author | pubmed-author:HjelmelandL... | lld:pubmed |
| pubmed-article:9593635 | pubmed:author | pubmed-author:HandaJ TJT | lld:pubmed |
| pubmed-article:9593635 | pubmed:copyrightInfo | Copyright 1998 Academic Press Limited. | lld:pubmed |
| pubmed-article:9593635 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9593635 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:9593635 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9593635 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9593635 | pubmed:pagination | 411-9 | lld:pubmed |
| pubmed-article:9593635 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:meshHeading | pubmed-meshheading:9593635-... | lld:pubmed |
| pubmed-article:9593635 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9593635 | pubmed:articleTitle | The advanced glycation endproduct pentosidine induces the expression of PDGF-B in human retinal pigment epithelial cells. | lld:pubmed |
| pubmed-article:9593635 | pubmed:affiliation | Department of Ophthalmology, University of California, Davis, CA 95616-8794, USA. | lld:pubmed |
| pubmed-article:9593635 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9593635 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9593635 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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