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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-7-2
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pubmed:abstractText |
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-2422386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-2441068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-2472961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-2953976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-50402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-6193623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-7684757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-7706824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-7914261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-7934937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-7968530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-8192448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-8192450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-8381814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-8723463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9593173-8971706
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1295-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9593173-Amikacin,
pubmed-meshheading:9593173-Antitubercular Agents,
pubmed-meshheading:9593173-Drug Resistance, Multiple,
pubmed-meshheading:9593173-Drug Therapy, Combination,
pubmed-meshheading:9593173-Genes, Bacterial,
pubmed-meshheading:9593173-Humans,
pubmed-meshheading:9593173-Kanamycin,
pubmed-meshheading:9593173-Kanamycin Resistance,
pubmed-meshheading:9593173-Mutation,
pubmed-meshheading:9593173-Mycobacterium tuberculosis
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pubmed:year |
1998
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pubmed:articleTitle |
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
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pubmed:affiliation |
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. galangaden@oncgate.roc.wayne.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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