rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1998-7-8
|
pubmed:abstractText |
Noribogaine is formed in vivo by the O-demethylation of the indole alkaloid ibogaine. We report here that noribogaine acts as a full agonist at the mu-opioid receptor. Noribogaine-stimulated guanylyl 5'gamma-[35S]thio]triphosphate ([35S]GTPgammaS) was studied in rat thalamic membranes to measure activation of guanine nucleotide binding proteins (G-proteins) in the presence of excess GDP. Noribogaine caused a 170% increase above basal [35S]GTPgammaS binding at sub-micromolar effective concentrations (EC50) in a naloxone-sensitive manner, confirming that this effect was an opioid receptor-mediated process. The level of intrinsic activity for noribogaine in these assays was comparable to the full agonists DAMGO and morphine. In contrast, ibogaine had no significant effect on [35S]GTPgammaS binding over a similar concentration range. The efficacy of noribogaine as a full mu-opioid agonist may explain ibogaine's ability to block the acute signs of opiate withdrawal and its suppressive effects on morphine self-administration.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine 5'-O-(3-Thiotriphosphate),
http://linkedlifedata.com/resource/pubmed/chemical/Ibogaine,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfur Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/noribogaine
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0959-4965
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
5
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
109-14
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9592058-Animals,
pubmed-meshheading:9592058-Binding, Competitive,
pubmed-meshheading:9592058-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:9592058-Enkephalins,
pubmed-meshheading:9592058-Guanosine 5'-O-(3-Thiotriphosphate),
pubmed-meshheading:9592058-Ibogaine,
pubmed-meshheading:9592058-Logistic Models,
pubmed-meshheading:9592058-Male,
pubmed-meshheading:9592058-Naloxone,
pubmed-meshheading:9592058-Radioligand Assay,
pubmed-meshheading:9592058-Rats,
pubmed-meshheading:9592058-Rats, Sprague-Dawley,
pubmed-meshheading:9592058-Receptors, Opioid, mu,
pubmed-meshheading:9592058-Stimulation, Chemical,
pubmed-meshheading:9592058-Sulfur Radioisotopes
|
pubmed:year |
1998
|
pubmed:articleTitle |
Noribogaine stimulates naloxone-sensitive [35S]GTPgammaS binding.
|
pubmed:affiliation |
Department of Neurology, University of Miami School of Medicine, FL 33136, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|