|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007137,
umls-concept:C0008838,
umls-concept:C0013215,
umls-concept:C0040845,
umls-concept:C0205179,
umls-concept:C0332120,
umls-concept:C0460004,
umls-concept:C0751177,
umls-concept:C0751688,
umls-concept:C0920321,
umls-concept:C1517004,
umls-concept:C1527178,
umls-concept:C1705938
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1998-6-2
|
|
pubmed:abstractText |
Cis-platinum and 13-cis-retinoic acid have received much attention in the treatment of head and neck squamous cell cancer. Even though they have different mechanisms of action, little information is available on their interaction. This paper reviews experimental evidence for retinoic acid-cis-platinum synergy and presents toxicity data from patients with stage IV head and neck squamous cell cancer participating in a phase I trial combining 13-cis-retinoic acid and cis-platinum.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0194-5998
|
|
pubmed:author |
pubmed-author:ChristenRR,
pubmed-author:GlassmeyerSS,
pubmed-author:HowellSS,
pubmed-author:JonesVV,
pubmed-author:KerberCC,
pubmed-author:KirmaniSS,
pubmed-author:LotFF,
pubmed-author:OrloffL ALA,
pubmed-author:SeagrenSS,
pubmed-author:VEALJ RJR,
pubmed-author:WeismanR ARA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
118
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
597-602
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9591856-Administration, Oral,
pubmed-meshheading:9591856-Adult,
pubmed-meshheading:9591856-Aged,
pubmed-meshheading:9591856-Antineoplastic Agents,
pubmed-meshheading:9591856-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9591856-Carcinoma, Squamous Cell,
pubmed-meshheading:9591856-Cisplatin,
pubmed-meshheading:9591856-Cohort Studies,
pubmed-meshheading:9591856-Drug Administration Schedule,
pubmed-meshheading:9591856-Drug Synergism,
pubmed-meshheading:9591856-Female,
pubmed-meshheading:9591856-Head and Neck Neoplasms,
pubmed-meshheading:9591856-Humans,
pubmed-meshheading:9591856-Injections, Intra-Arterial,
pubmed-meshheading:9591856-Isotretinoin,
pubmed-meshheading:9591856-Male,
pubmed-meshheading:9591856-Middle Aged,
pubmed-meshheading:9591856-Neoplasm Staging,
pubmed-meshheading:9591856-Radiotherapy, Adjuvant,
pubmed-meshheading:9591856-Remission Induction,
pubmed-meshheading:9591856-Survival Rate,
pubmed-meshheading:9591856-Treatment Outcome
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Phase I trial of retinoic acid and cis-platinum for advanced squamous cell cancer of the head and neck based on experimental evidence of drug synergism.
|
|
pubmed:affiliation |
Department of Surgery, University of California, San Diego, San Diego Veterans Administration Medical Center, USA.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
|
