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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-6-11
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pubmed:abstractText |
The novel radioimmunoconjugate, 90Y-DOTA-peptide-chimeric L6 (ChL6), was designed to reduce radiation to critical normal tissues with an exceptionally stable 90Y chelate moiety and a biodegradable linker. Human breast cancer tumors (HBT 3477) in mice were treated with 90Y-DOTA-peptide-ChL6 to examine the effects of increasing dose on the therapeutic efficacy and toxicity of this new agent.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5505
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pubmed:author |
pubmed-author:DeNardoG LGL,
pubmed-author:DeNardoS JSJ,
pubmed-author:GumerlockP HPH,
pubmed-author:KrogerL ALA,
pubmed-author:KukisD LDL,
pubmed-author:LambornK RKR,
pubmed-author:MearesC FCF,
pubmed-author:MiersL ALA,
pubmed-author:SalakoQQ,
pubmed-author:ShenSS,
pubmed-author:WinthropM DMD
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-9
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pubmed:dateRevised |
2011-7-29
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pubmed:meshHeading |
pubmed-meshheading:9591587-Adenocarcinoma,
pubmed-meshheading:9591587-Animals,
pubmed-meshheading:9591587-Antibodies, Monoclonal,
pubmed-meshheading:9591587-Apoptosis,
pubmed-meshheading:9591587-Breast Neoplasms,
pubmed-meshheading:9591587-Dose-Response Relationship, Radiation,
pubmed-meshheading:9591587-Female,
pubmed-meshheading:9591587-Heterocyclic Compounds,
pubmed-meshheading:9591587-Humans,
pubmed-meshheading:9591587-Lethal Dose 50,
pubmed-meshheading:9591587-Mice,
pubmed-meshheading:9591587-Mice, Nude,
pubmed-meshheading:9591587-Neoplasm Transplantation,
pubmed-meshheading:9591587-Oligopeptides,
pubmed-meshheading:9591587-Radioimmunotherapy,
pubmed-meshheading:9591587-Transplantation, Heterologous,
pubmed-meshheading:9591587-Tumor Suppressor Protein p53,
pubmed-meshheading:9591587-Yttrium,
pubmed-meshheading:9591587-Yttrium Radioisotopes
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pubmed:year |
1998
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pubmed:articleTitle |
Yttrium-90-DOTA-peptide-chimeric L6 radioimmunoconjugate: efficacy and toxicity in mice bearing p53 mutant human breast cancer xenografts.
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pubmed:affiliation |
Department of Internal Medicine, University of California Davis Medical Center, Sacramento, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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