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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1998-6-18
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pubmed:abstractText |
Molecular analysis of hyperunstable mutations in the adjacent yellow and scute loci was performed in a Drosophila melanogaster strain y2ns scme obtained earlier. The y2ns scme combination originated from the original y+ns mutation associated with the insertion into the regulatory region of the yellow gene of a chimeric sequence flanked by deletion copies of the P element. The new combination of mutations resulted from an inversion between P-element copies located in the adjacent yellow and scute loci. The inversion was flanked by two P-element copies at one side and one copy at the other side. All three P-element copies had various internal deletions and, therefore, could not code for active transposase. An introduction of the delta (2-3) gene for transposase induced mutagenesis in the y2ns scme strain. Most mutations observed were associated with either excision of a single P-element copy or reinversion resulting from the recombination between the ends of P elements located in the yellow and scute genes. Genetic analysis showed that the alleles resulting from the recombination at a high frequency reverted to the original state.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0016-6758
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
343-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9589862-Alleles,
pubmed-meshheading:9589862-Animals,
pubmed-meshheading:9589862-Chromosome Deletion,
pubmed-meshheading:9589862-Chromosome Mapping,
pubmed-meshheading:9589862-Cloning, Molecular,
pubmed-meshheading:9589862-Drosophila melanogaster,
pubmed-meshheading:9589862-Genes, Insect,
pubmed-meshheading:9589862-Mutagenesis, Insertional,
pubmed-meshheading:9589862-Phenotype,
pubmed-meshheading:9589862-Pigmentation,
pubmed-meshheading:9589862-Point Mutation,
pubmed-meshheading:9589862-Polymerase Chain Reaction,
pubmed-meshheading:9589862-Sequence Analysis, DNA
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pubmed:year |
1998
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pubmed:articleTitle |
[Molecular analysis of a double hyperunstable system y(2ns)sc(me)].
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pubmed:affiliation |
Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. elenag@mx.ibg.rssi.ru
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pubmed:publicationType |
Journal Article,
English Abstract
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