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rdf:type |
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lifeskim:mentions |
umls-concept:C0007452,
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0085828,
umls-concept:C0144576,
umls-concept:C0162745,
umls-concept:C0164371,
umls-concept:C0185117,
umls-concept:C0225369,
umls-concept:C0441655,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
1998-6-1
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pubmed:abstractText |
Cytokine-induced collagenase 1 (matrix metalloproteinase 1 [MMP-1]) and stromelysin 1 (MMP-3) expression is dependent on activator protein 1 (AP-1) activation and have a fundamental role in the pathophysiology of arthritic diseases by degrading connective tissues. This study evaluates the effect of paclitaxel on AP-1 activation and examines its effect on the expression of 2 major matrix metalloproteinases, MMP-1 and MMP-3, and its effect on AP-1 activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Chloramphenicol O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagenases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
869-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9588740-Aggrecans,
pubmed-meshheading:9588740-Animals,
pubmed-meshheading:9588740-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9588740-Cartilage, Articular,
pubmed-meshheading:9588740-Cattle,
pubmed-meshheading:9588740-Cell Survival,
pubmed-meshheading:9588740-Cells, Cultured,
pubmed-meshheading:9588740-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:9588740-Chondrocytes,
pubmed-meshheading:9588740-Collagen,
pubmed-meshheading:9588740-Collagenases,
pubmed-meshheading:9588740-DNA Primers,
pubmed-meshheading:9588740-Extracellular Matrix Proteins,
pubmed-meshheading:9588740-Interleukin-1,
pubmed-meshheading:9588740-Lectins, C-Type,
pubmed-meshheading:9588740-Matrix Metalloproteinase 1,
pubmed-meshheading:9588740-Matrix Metalloproteinase 3,
pubmed-meshheading:9588740-Paclitaxel,
pubmed-meshheading:9588740-Proteoglycans,
pubmed-meshheading:9588740-RNA, Messenger,
pubmed-meshheading:9588740-Transcription Factor AP-1
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pubmed:year |
1998
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pubmed:articleTitle |
Inhibition of activator protein 1 activity by paclitaxel suppresses interleukin-1-induced collagenase and stromelysin expression by bovine chondrocytes.
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pubmed:affiliation |
Mount Sinai Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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