Linked Life Data

9588695

Source:http://linkedlifedata.com/resource/pubmed/id/9588695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-6-18
pubmed:abstractText
Recent reports suggest that estrogens may enhance cognitive function in postmenopausal women and women suffering from dementia of the Alzheimer's type. One of several proposed mechanisms of action of estrogen has been an improvement in cerebral blood flow (CBF). The current study examined the effects of estrogen deprivation resulting from ovariectomy on the CBF of rats using the quantitative autoradiographic 14C-iodoantipyrine technique. CBF was assessed in passively restrained, awake adult rats at 6 weeks following ovariectomy (n = 10) or sham surgery (n = 10). Rats demonstrated marked endometrial atrophy and a decrease in uterine weight (mean 78%) in response to ovariectomy. Ovariectomized animals did not differ from control animals both in the magnitude and the topography of cortical or subcortical CBF, including the medial preoptic area, amygdala, arcuate nucleus and anterior hypothalamus, areas previously associated with high estrogen binding. These results suggest that in young, surgically ovariectomized animals, hormonal factors do not significantly contribute to changes in basal CBF.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Effects of ovariectomy on cerebral flow of rats.
pubmed:affiliation
Department of Psychiatry and the Behavioral Sciences, University of Southern California, School of Medicine, Los Angeles, USA. holschne@hsc.usc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.