Linked Life Data

9587036

Source:http://linkedlifedata.com/resource/pubmed/id/9587036

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-7-14
pubmed:abstractText
Hyperhomocysteinaemia is a risk factor for atherothrombotic disease, but data are limited on the arterial histology in humans with hyperhomocysteinaemia, either with or without other risk factors. Studies in vitro and in animals have shown that hyperhomocysteinaemia, possibly by increasing oxidant stress as well as by other mechanisms, may induce dysfunction of the vascular endothelium and proliferation of vascular smooth muscle cells, both key processes in atherogenesis. In clinically healthy subjects with hyperhomocysteinaemia, endothelium-dependent vasodilation may be impaired, but endothelial antithrombotic and profibrinolytic function appear normal at this stage. In patients with atherosclerosis and hyperhomocysteinaemia, endothelial antithrombotic properties appear more severely impaired than in similar patients with normohomocysteinaemia. Controlled data on the effects of homocysteine-lowering treatment on vascular function in humans are not available. The increased risk of atherothrombotic disease conferred by hyperhomocysteinaemia may be related to homocysteine-associated impairments in endothelial and vascular smooth muscle cell function. The precise mechanisms by which homocysteine affects vascular cell function, however, are unknown.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0340-6199
pubmed:author
pubmed:issnType
Print
pubmed:volume
157 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S107-11
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Abnormalities of vascular function in hyperhomocysteinaemia: relationship to atherothrombotic disease.
pubmed:affiliation
Department of Internal Medicine, Academisch Ziekenhuis Vrije Universiteit, and Institute for Cardiovascular Research, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Review