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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1998-7-14
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pubmed:abstractText |
Deficient activity of an enzyme can result from a defect in the conversion of the vitamin to a co-enzyme as well from an abnormal apo-enzyme or disturbed binding of coenzyme to enzyme. Conversion of dietary vitamin to intracellular active co-enzyme can be complex and require many physiological and biochemical processes including stomach release of bound vitamin, intestinal uptake, carriers/transport, blood transport, cellular uptake, intracellular release and intracellular compartmentalisation. Disorders of malabsorption (food cobalamin malabsorption, intrinsic factor deficiency and abnormal enterocyte cobalamin processing) and transport proteins (transcobalamin II deficiency, R-binder deficiency) mostly lead to disturbed function of the two cobalamin requiring enzymes, methylmalonyl CoA mutase and methionine synthase. Defects of early steps of intracellular cobalamin (cblF, cbl C/D) result in marked deficiencies of both cobalamin co-enzymes and homocystinuria combined with methylmalonic aciduria. Defective synthesis of adenosyl cobalamin in the cbl A/B defects leads to methylmalonyl CoA mutase. Isolated methionine synthase deficiency is also classified as a cobalamin disorder due to its associated deficient formation of methylcobalamin. Folate disorders include methylene-tetrahydrofolate reductase deficiency and glutamate formimino-transferase deficiency. In addition a hereditary disorder of intestinal folate transport has been described. Less well established are disorders of dihydrofolate reductase, methenyl-tetrahydrofolate cyclohydrolase, and defects of cellular folate uptake.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,6,7,8-tetrahydrofolic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Coenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Homocysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Methylenetetrahydrofolate...,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases Acting on CH-NH...,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolates,
http://linkedlifedata.com/resource/pubmed/chemical/Transcobalamins,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin B 12
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0340-6199
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
157 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S60-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9587028-Absorption,
pubmed-meshheading:9587028-Amino Acid Metabolism, Inborn Errors,
pubmed-meshheading:9587028-Animals,
pubmed-meshheading:9587028-Coenzymes,
pubmed-meshheading:9587028-Fibroblasts,
pubmed-meshheading:9587028-Folic Acid,
pubmed-meshheading:9587028-Homocysteine,
pubmed-meshheading:9587028-Humans,
pubmed-meshheading:9587028-Lysosomes,
pubmed-meshheading:9587028-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:9587028-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:9587028-Tetrahydrofolates,
pubmed-meshheading:9587028-Transcobalamins,
pubmed-meshheading:9587028-Vitamin B 12
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pubmed:year |
1998
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pubmed:articleTitle |
Genetic defects of folate and cobalamin metabolism.
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pubmed:affiliation |
University Children's Hospital, Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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