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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-6-26
|
| pubmed:abstractText |
Isolation rearing of rats produces a behavioral syndrome indicative of altered dopamine (DA) function in the nucleus accumbens (NAC). The present experiments extend these findings by investigating: (a) interactions between isolation rearing and repeated handling/testing on presynaptic DA function in the NAC using in vivo microdialysis: (b) the dose-response curve for the effects of d-amphetamine, and the responses elicited by high potassium, using in vivo microdialysis, and (c) postsynaptic function in isolates as indexed by DA receptor-linked cAMP production. Experiment 1 showed that both isolation rearing and repeated handling/testing had effects on monoamine function in the NAC. However, while both manipulations enhanced DA release evoked by d-amphetamine, only isolated rats had elevated basal DA levels. Opposite neurochemical changes were observed with respect to the serotonin metabolite 5-HIAA, isolates having lower, and repeatedly handled/tested animals having higher, extracellular levels. Experiment 2 provided evidence for enhanced d-amphetamine-evoked DA release in isolated animals, while potassium-evoked DA release was reduced. Experiment 3 provided evidence that the isolation rearing induced changes in presynaptic DA function were accompanied by postsynaptic changes. Specifically, the inhibitory influence of the D2 receptor on D1 receptor-stimulated cAMP production was attenuated in ventral striatal slices taken from isolates, suggesting a functional downregulation of D2 receptors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0091-3057
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
859-72
|
| pubmed:dateRevised |
2010-8-25
|
| pubmed:meshHeading |
pubmed-meshheading:9586842-Animals,
pubmed-meshheading:9586842-Behavior, Animal,
pubmed-meshheading:9586842-Chromatography, High Pressure Liquid,
pubmed-meshheading:9586842-Dextroamphetamine,
pubmed-meshheading:9586842-Dopamine,
pubmed-meshheading:9586842-Dopamine Antagonists,
pubmed-meshheading:9586842-Dopamine Uptake Inhibitors,
pubmed-meshheading:9586842-Dose-Response Relationship, Drug,
pubmed-meshheading:9586842-Handling (Psychology),
pubmed-meshheading:9586842-Male,
pubmed-meshheading:9586842-Microdialysis,
pubmed-meshheading:9586842-Motor Activity,
pubmed-meshheading:9586842-Neostriatum,
pubmed-meshheading:9586842-Rats,
pubmed-meshheading:9586842-Social Isolation,
pubmed-meshheading:9586842-Sulpiride,
pubmed-meshheading:9586842-Synapses,
pubmed-meshheading:9586842-Weight Gain
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems.
|
| pubmed:affiliation |
Department of Experimental Psychology, University of Cambridge, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|