|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1998-5-26
|
|
pubmed:abstractText |
A role for the Fc receptor beta chain (FcRbeta) in the pathogenesis of allergy has been suggested by genetic studies. FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRbeta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcepsilonRI- and FcgammaRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRbeta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1074-7613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
517-29
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9586641-Anaphylaxis,
pubmed-meshheading:9586641-Animals,
pubmed-meshheading:9586641-Calcium,
pubmed-meshheading:9586641-Cell Degranulation,
pubmed-meshheading:9586641-Humans,
pubmed-meshheading:9586641-Hypersensitivity,
pubmed-meshheading:9586641-Immunoglobulin E,
pubmed-meshheading:9586641-Immunoglobulin G,
pubmed-meshheading:9586641-Interleukin-6,
pubmed-meshheading:9586641-Mast Cells,
pubmed-meshheading:9586641-Mice,
pubmed-meshheading:9586641-Mice, Inbred BALB C,
pubmed-meshheading:9586641-Mice, Knockout,
pubmed-meshheading:9586641-Mice, Transgenic,
pubmed-meshheading:9586641-Models, Biological,
pubmed-meshheading:9586641-Phosphorylation,
pubmed-meshheading:9586641-Receptors, IgE,
pubmed-meshheading:9586641-Receptors, IgG,
pubmed-meshheading:9586641-Signal Transduction
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses.
|
|
pubmed:affiliation |
Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
