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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
37
|
| pubmed:dateCreated |
1998-7-23
|
| pubmed:abstractText |
Searching for more effective antineoplastic and antiviral agents, we have prepared various 2'-deoxy-2'-fluoro-4'-thioarabinonucleosides. The glycosylation reaction of persilylated pyrimidine bases with a 4-thiosugar derivative was performed using SnCl4 as a catalyst. The same reaction between purines and the 4-thiosugar, catalyzed by TMSOTf, gave the corresponding purine 4'-thionucleosides. Pyrimidine derivatives (e.g., 5-ethyluracil, 5-iodouracil, and 5-iodocytosine) showed potent anti-HSV-1 activities, and guanine and 2,6-diaminopurine derivatives showed marked anti-HCMV activities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0261-3166
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
43-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9585990-Antimetabolites, Antineoplastic,
pubmed-meshheading:9585990-Antiviral Agents,
pubmed-meshheading:9585990-Catalysis,
pubmed-meshheading:9585990-Herpesvirus 1, Human,
pubmed-meshheading:9585990-Humans,
pubmed-meshheading:9585990-Indicators and Reagents,
pubmed-meshheading:9585990-KB Cells,
pubmed-meshheading:9585990-Leukemia, T-Cell,
pubmed-meshheading:9585990-Molecular Structure,
pubmed-meshheading:9585990-Structure-Activity Relationship,
pubmed-meshheading:9585990-Thionucleosides,
pubmed-meshheading:9585990-Tumor Cells, Cultured
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Synthesis of 2'-deoxy-2'-fluoro-4'-thioarabinonucleosides using the Pummerer rearrangement and their biological evaluation.
|
| pubmed:affiliation |
Biochemicals Division, Yamasa Corporation, Chiba, Japan.
|
| pubmed:publicationType |
Journal Article
|