Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-6-24
|
| pubmed:abstractText |
There is genetic predisposition associated with >=10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric and nonparametric linkage (NPL) analysis allowed identification of a locus, on chromosome 1q42.2-43, carrying a putative predisposing gene for CaP (PCaP). The primary localization was confirmed with several markers, by use of three different genetic models. We obtained a maximum two-point LOD score of 2.7 with marker D1S2785. Multipoint parametric and NPL analysis yielded maximum HLOD and NPL scores of 2.2 and 3.1, respectively, with an associated P value of . 001. Homogeneity analysis with multipoint LOD scores gave an estimate of the proportion of families with linkage to this locus of 50%, with a likelihood ratio of 157/1 in favor of heterogeneity. Furthermore, the 9/47 families with early-onset CaP at age <60 years gave multipoint LOD and NPL scores of 3.31 and 3.32, respectively, with P = .001.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0002-9297
|
| pubmed:author |
pubmed-author:BachnerLL,
pubmed-author:Bellané-ChantelotCC,
pubmed-author:BerthonPP,
pubmed-author:BlanchéHH,
pubmed-author:ChumakovII,
pubmed-author:Cohen-AkenineAA,
pubmed-author:CohenNN,
pubmed-author:CussenotOO,
pubmed-author:DemenaisFF,
pubmed-author:DrelonEE,
pubmed-author:FournierGG,
pubmed-author:HautmannRR,
pubmed-author:LatilAA,
pubmed-author:Le DucAA,
pubmed-author:LidereauRR,
pubmed-author:MaitlandN JNJ,
pubmed-author:ManginPP,
pubmed-author:MellahII,
pubmed-author:MillasseauPP,
pubmed-author:PaissTT,
pubmed-author:TeillacPP,
pubmed-author:ValereMM,
pubmed-author:VogelWW,
pubmed-author:WöhrGG,
pubmed-author:de PetriconiRR
|
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
1416-24
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9585607-Age of Onset,
pubmed-meshheading:9585607-Chromosome Mapping,
pubmed-meshheading:9585607-Chromosomes, Human, Pair 1,
pubmed-meshheading:9585607-Genetic Heterogeneity,
pubmed-meshheading:9585607-Genetic Linkage,
pubmed-meshheading:9585607-Genetic Predisposition to Disease,
pubmed-meshheading:9585607-Genotype,
pubmed-meshheading:9585607-Humans,
pubmed-meshheading:9585607-Lod Score,
pubmed-meshheading:9585607-Male,
pubmed-meshheading:9585607-Microsatellite Repeats,
pubmed-meshheading:9585607-Prostatic Neoplasms
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43.
|
| pubmed:affiliation |
Département d'Urologie, Université Paris VII, Hôpital Saint Louis, Paris, France. p.berthon@chu-stlouis.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|