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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-5-21
|
| pubmed:abstractText |
The aim of this study was to assess neurological, neuropsychological, and neuroradiological findings in long-term survivors of allogeneic bone marrow transplantation (BMT) who were recruited from a hematological outpatient clinic. In addition, risk factors for the development of late neurological complications were identified. In contrast to previous studies on autopsied patients, our study design provoked a bias away from increased neurological sequelae, because patients with early complications after BMT were excluded. Fifty-nine allogeneic patients and 7 autologous BMT patients underwent clinical examination, short neuropsychological testing, and cranial magnetic resonance imaging (MRI) 34 +/- 26 months after BMT. The pathological results of the neurological examination (abnormal 64%) and the MRI examination (white matter lesions, 54%; atrophy, 11%) were associated with the occurrence of chronic graft-versus-host disease (GvHD) evolving from acute GvHD, with corticosteroid therapy and with cyclosporine medication. Neuropsychological impairment (cognitive deficits, 37%) was associated with long-term cyclosporine medication and age. No influence of pre-BMT disease, BMT donor status, or the conditioning regimen was found. These results suggest that the frequent neurological abnormalities in long-term survivors of allogeneic BMT are associated with chronic GvHD and with the resulting immunosuppression as major risk factors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0364-5134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
627-33
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9585357-Adult,
pubmed-meshheading:9585357-Bone Marrow Transplantation,
pubmed-meshheading:9585357-Brain Diseases,
pubmed-meshheading:9585357-Cognition Disorders,
pubmed-meshheading:9585357-Female,
pubmed-meshheading:9585357-Follow-Up Studies,
pubmed-meshheading:9585357-Graft vs Host Disease,
pubmed-meshheading:9585357-Humans,
pubmed-meshheading:9585357-Magnetic Resonance Imaging,
pubmed-meshheading:9585357-Male,
pubmed-meshheading:9585357-Middle Aged,
pubmed-meshheading:9585357-Postoperative Complications,
pubmed-meshheading:9585357-Risk Factors,
pubmed-meshheading:9585357-Transplantation, Homologous
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Neurological and neuroradiological findings in long-term survivors of allogeneic bone marrow transplantation.
|
| pubmed:affiliation |
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.
|
| pubmed:publicationType |
Journal Article
|