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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-6-23
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pubmed:abstractText |
The interferons (IFNs) have been extensively studied in the context of host defence against viral infection. In the established model of IFN action, virally infected cells secrete type I IFNs (IFN-alpha/beta) which induce an antiviral state in uninfected cells. However, it is not clear how IFNs function on the infected cells. It has been reported that cells infected by some viruses die by apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ifnar1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Poly I-C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Double-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Interferon alpha-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1356-9597
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-37
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9581980-Animals,
pubmed-meshheading:9581980-Antibodies,
pubmed-meshheading:9581980-Antiviral Agents,
pubmed-meshheading:9581980-Apoptosis,
pubmed-meshheading:9581980-DNA-Binding Proteins,
pubmed-meshheading:9581980-Encephalomyocarditis virus,
pubmed-meshheading:9581980-Flow Cytometry,
pubmed-meshheading:9581980-Gene Expression Regulation,
pubmed-meshheading:9581980-Immunohistochemistry,
pubmed-meshheading:9581980-Interferon Type I,
pubmed-meshheading:9581980-Membrane Proteins,
pubmed-meshheading:9581980-Mice,
pubmed-meshheading:9581980-Poly I-C,
pubmed-meshheading:9581980-RNA, Double-Stranded,
pubmed-meshheading:9581980-Receptor, Interferon alpha-beta,
pubmed-meshheading:9581980-Receptors, Interferon,
pubmed-meshheading:9581980-STAT1 Transcription Factor,
pubmed-meshheading:9581980-Signal Transduction,
pubmed-meshheading:9581980-Simplexvirus,
pubmed-meshheading:9581980-Trans-Activators,
pubmed-meshheading:9581980-Vesicular stomatitis Indiana virus
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pubmed:year |
1998
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pubmed:articleTitle |
Type I interferons are essential mediators of apoptotic death in virally infected cells.
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pubmed:affiliation |
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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