| pubmed-article:9581895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C0030657 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C0037224 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C0024398 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C0042232 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C1522570 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C0458083 | lld:lifeskim |
| pubmed-article:9581895 | lifeskim:mentions | umls-concept:C1710198 | lld:lifeskim |
| pubmed-article:9581895 | pubmed:dateCreated | 1998-6-17 | lld:pubmed |
| pubmed-article:9581895 | pubmed:abstractText | Cell associated and cell-free simian immunodeficiency virus (SIV) were used to investigate transmission of SIV across the vaginal mucosa of rhesus macaques. The intact vaginal epithelium was found to be a strong but penetrable barrier to cell-free SIV infection. We found that 10,000-fold more cell-free SIV was needed to infect 100% of the macaques by the vaginal route when compared to the dose needed to infect 100% by the intravenous (i.v.) route. Like cell-free SIV, cell-associated SIV was an efficient means of transmission if given by the i.v. route; as few as 2 SIV-infected peripheral blood mononuclear cells (PBMC) were infectious inoculum. However, macaques were resistant to cell-associated SIV when exposed by the vaginal route; 10,000 SIV-infected PBMC failed to infect vaginally inoculated macaques. It was also found that vaginal transmission of cell-free SIV to macaques increased during the luteal phase of the menstrual cycle compared to the follicular phase. Results with this animal model predict that cell-free human immunodeficiency virus (HIV) is likely to be the more efficient mode of HIV vaginal transmission and that susceptibility may vary during the menstrual cycle. | lld:pubmed |
| pubmed-article:9581895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9581895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9581895 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9581895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9581895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9581895 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9581895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9581895 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9581895 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:9581895 | pubmed:author | pubmed-author:MillerC JCJ | lld:pubmed |
| pubmed-article:9581895 | pubmed:author | pubmed-author:MarxP APA | lld:pubmed |
| pubmed-article:9581895 | pubmed:author | pubmed-author:GettieAA | lld:pubmed |
| pubmed-article:9581895 | pubmed:author | pubmed-author:SodoraD LDL | lld:pubmed |
| pubmed-article:9581895 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9581895 | pubmed:volume | 14 Suppl 1 | lld:pubmed |
| pubmed-article:9581895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9581895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9581895 | pubmed:pagination | S119-23 | lld:pubmed |
| pubmed-article:9581895 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
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| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
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| pubmed-article:9581895 | pubmed:meshHeading | pubmed-meshheading:9581895-... | lld:pubmed |
| pubmed-article:9581895 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9581895 | pubmed:articleTitle | Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks. | lld:pubmed |
| pubmed-article:9581895 | pubmed:affiliation | Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. | lld:pubmed |
| pubmed-article:9581895 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9581895 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9581895 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9581895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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