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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1998-6-17
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pubmed:abstractText |
Cell associated and cell-free simian immunodeficiency virus (SIV) were used to investigate transmission of SIV across the vaginal mucosa of rhesus macaques. The intact vaginal epithelium was found to be a strong but penetrable barrier to cell-free SIV infection. We found that 10,000-fold more cell-free SIV was needed to infect 100% of the macaques by the vaginal route when compared to the dose needed to infect 100% by the intravenous (i.v.) route. Like cell-free SIV, cell-associated SIV was an efficient means of transmission if given by the i.v. route; as few as 2 SIV-infected peripheral blood mononuclear cells (PBMC) were infectious inoculum. However, macaques were resistant to cell-associated SIV when exposed by the vaginal route; 10,000 SIV-infected PBMC failed to infect vaginally inoculated macaques. It was also found that vaginal transmission of cell-free SIV to macaques increased during the luteal phase of the menstrual cycle compared to the follicular phase. Results with this animal model predict that cell-free human immunodeficiency virus (HIV) is likely to be the more efficient mode of HIV vaginal transmission and that susceptibility may vary during the menstrual cycle.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0889-2229
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S119-23
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9581895-Animals,
pubmed-meshheading:9581895-Cells, Cultured,
pubmed-meshheading:9581895-Disease Progression,
pubmed-meshheading:9581895-Female,
pubmed-meshheading:9581895-Humans,
pubmed-meshheading:9581895-Leukocytes, Mononuclear,
pubmed-meshheading:9581895-Macaca mulatta,
pubmed-meshheading:9581895-Menstrual Cycle,
pubmed-meshheading:9581895-Mucous Membrane,
pubmed-meshheading:9581895-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9581895-Simian immunodeficiency virus,
pubmed-meshheading:9581895-Vagina,
pubmed-meshheading:9581895-Viral Load
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pubmed:year |
1998
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pubmed:articleTitle |
Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks.
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pubmed:affiliation |
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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