Linked Life Data

9581026

Source:http://linkedlifedata.com/resource/pubmed/id/9581026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-5-28
pubmed:abstractText
Previous studies have demonstrated that the toxicokinetics of a single oral dose of inorganic mercury in mice depends on the specific strain. The strain dependent kinetics were attributed primarily to differences in intestinal Hg2+ absorption. Elimination kinetics have been difficult to evaluate, however, as the majority of a single oral dose will pass through the gastrointestinal tract unabsorbed. Therefore, in contrast to previous studies, in this study exposure to inorganic mercury in drinking water for a prolonged time period was used in order to reach a steady state for whole-body retention of mercury. The exposure level (5 mg l-1) was sufficiently low to exclude gastrointestinal toxicity. The steady-state retention of mercury was established in four inbred mouse strains (B10.S, DBA, A.SW and SJL). The DBA strain reached the highest whole-body steady state level of mercury (19 micrograms Hg) whereas B10.S mice, when considering the drinking water consumption, had the lowest steady-state retention of mercury (15 micrograms Hg). Analysis of the whole-body elimination of mercury after 12 weeks of drinking water exposure indicated that variations in the elimination kinetics could explain a large fraction of the observed strain differences in the steady-state retention of mercury. Thus, the approximate half-time for elimination of aged mercury depots was longest in DBA mice (83 d) and shortest in B10.S mice (44 d). Further, the observed organ depositions indicated that differences in the transport of mercury from the liver to kidney might also explain some of the differences in the elimination kinetics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0003-2654
pubmed:author
pubmed:issnType
Print
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Strain dependence of steady-state retention and elimination of mercury in mice after prolonged exposure to mercury(II) chloride.
pubmed:affiliation
Department of Environmental Medicine, Odense University, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't