Linked Life Data

9580059

Source:http://linkedlifedata.com/resource/pubmed/id/9580059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1998-4-3
pubmed:abstractText
The effect of three different receptor-specific adenosine agonists on the rate of ureagenesis by isolated rat hepatocytes and the dependence on the external free Ca2+ concentration ([Ca2+]e) were investigated. In the presence of high [Ca2+]e all adenosine receptor agonists increased ureagenesis to similar levels. However, with low [Ca2+]e the effects of each agonist varied as follows: (i) the adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyl-adenosine, increased ureagenesis depending partially on [Ca2+]e, (ii) the adenosine receptor A2 agonist, 2-p-(-2-carboxy-ethyl) phenethylamino-5'-N-ethylcarboxyamido adenosine hydrochloride, increased ureagenesis independently of [Ca2+]e and (iii) in contrast, the adenosine receptor A3 agonist N6-2-(-4-aminophenyl) ethyladenosine, increased ureagenesis only in the presence of high [Ca2+]e. The adenosine receptor A1 antagonist, 1-allyl-3,7-dimethyl-8-phenyl xanthine, inhibited the effect of the adenosine receptor A1 agonist on ureagenesis, but not the effect of the adenosine A2 or A3 receptor agonists. The adenosine A2 receptor antagonist, 3,7-dimethyl-1-propargylxanthine, inhibited only the effect of the adenosine A2 receptor agonist. Thus, in addition to A1 and A2 type adenosine receptors, rat hepatocytes possess an A3-like adenosine receptor which responds to the addition of an adenosine A3 agonist by accelerating ureagenesis a [Ca2+]e dependent manner. Moreover, it was observed that in the presence of extracellular Ca2+ each agonist increased [Ca2+]i and this effect was inhibited by the appropriate specific antagonist.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
340
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Ca2+ dependence of the response of three adenosine type receptors in rat hepatocytes.
pubmed:affiliation
Department of Biochemistry, School of Medicine, Universidad Nacional Autónoma de México, Mexico DF.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't