| pubmed-article:95787 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0086344 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C0872192 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:95787 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:95787 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:95787 | pubmed:dateCreated | 1993-7-22 | lld:pubmed |
| pubmed-article:95787 | pubmed:abstractText | T-cell DNA synthesis and T-helper cell function in response to isolated insulin chains and naturally occurring insulin variants was assessed in insulin immune guinea pigs. Two distinct antigenic determinants, recognized by T cells, were defined. One localized in the B chain and the other one constituted by amino acids A8, A9, and A10 of the insulin A-chain loop. Recognition of the B-chain determinant is under the control of Ir genes linked to the strain 13 major histocompatibility complex. This was shown by studying the response to isolated insulin B chain in F1(2 x 13) guinea pigs, as well as serologically defined backcrosses and outbred animals. Insulin recognition through the A-chain loop determinant is specific for strain 2 guinea pigs. These animals recognize this region of the molecule even when displaying different amino acid sequences. The strain differences observed in those antigenic sites eliciting T-cell recognition was not found at an antibody level. No differences could be detected in the ability of the different insulin variants to inhibit the binding of 125I-labeled pork insulin to strain 2 guinea pig anti-pork insulin or to strain 13 guinea pig anti-pork insulin. | lld:pubmed |
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| pubmed-article:95787 | pubmed:language | eng | lld:pubmed |
| pubmed-article:95787 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:95787 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:95787 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:95787 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:95787 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:95787 | pubmed:author | pubmed-author:RosenthalA... | lld:pubmed |
| pubmed-article:95787 | pubmed:author | pubmed-author:BarcinskiM... | lld:pubmed |
| pubmed-article:95787 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:95787 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:95787 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:95787 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:95787 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:95787 | pubmed:pagination | 726-42 | lld:pubmed |
| pubmed-article:95787 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:95787 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:95787 | pubmed:articleTitle | Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells. | lld:pubmed |
| pubmed-article:95787 | pubmed:affiliation | Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014. | lld:pubmed |
| pubmed-article:95787 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:95787 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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