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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-7-22
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pubmed:abstractText |
T-cell DNA synthesis and T-helper cell function in response to isolated insulin chains and naturally occurring insulin variants was assessed in insulin immune guinea pigs. Two distinct antigenic determinants, recognized by T cells, were defined. One localized in the B chain and the other one constituted by amino acids A8, A9, and A10 of the insulin A-chain loop. Recognition of the B-chain determinant is under the control of Ir genes linked to the strain 13 major histocompatibility complex. This was shown by studying the response to isolated insulin B chain in F1(2 x 13) guinea pigs, as well as serologically defined backcrosses and outbred animals. Insulin recognition through the A-chain loop determinant is specific for strain 2 guinea pigs. These animals recognize this region of the molecule even when displaying different amino acid sequences. The strain differences observed in those antigenic sites eliciting T-cell recognition was not found at an antibody level. No differences could be detected in the ability of the different insulin variants to inhibit the binding of 125I-labeled pork insulin to strain 2 guinea pig anti-pork insulin or to strain 13 guinea pig anti-pork insulin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-1082898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-1084404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-13867017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-13897619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-13912955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-169474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-175286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-19867233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4102686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4117550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4126770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4195496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4501590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4546918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4581398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4598890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-46912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-47221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4738905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4766957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-4979775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-5011012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-50400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-50566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-5121756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-5166455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-53189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-5428869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-55459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-57891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-58456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-5849238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-61870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-768405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/95787-802471
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
726-42
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:95787-Amino Acid Sequence,
pubmed-meshheading:95787-Animals,
pubmed-meshheading:95787-Antibody Specificity,
pubmed-meshheading:95787-B-Lymphocytes,
pubmed-meshheading:95787-Cell Division,
pubmed-meshheading:95787-Cells, Cultured,
pubmed-meshheading:95787-Epitopes,
pubmed-meshheading:95787-Genes, MHC Class II,
pubmed-meshheading:95787-Guinea Pigs,
pubmed-meshheading:95787-Insulin,
pubmed-meshheading:95787-Major Histocompatibility Complex,
pubmed-meshheading:95787-Molecular Sequence Data,
pubmed-meshheading:95787-Oxidation-Reduction,
pubmed-meshheading:95787-T-Lymphocytes
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pubmed:year |
1977
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pubmed:articleTitle |
Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.
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pubmed:affiliation |
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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