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rdf:type |
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lifeskim:mentions |
umls-concept:C0003691,
umls-concept:C0003695,
umls-concept:C0005821,
umls-concept:C0025124,
umls-concept:C0025519,
umls-concept:C0033551,
umls-concept:C0034493,
umls-concept:C0205409,
umls-concept:C0285721,
umls-concept:C1280500,
umls-concept:C1440044,
umls-concept:C2348678
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pubmed:issue |
2
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pubmed:dateCreated |
1998-6-24
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pubmed:abstractText |
The effects of daphnodorin A, B and C, isolated from the root and bark of Daphne odora THUNB, on the activities of 12-lipoxygenase and cyclooxygenase in rabbit platelets were examined. Daphnodorin A and C were inhibitors of platelet 12-lipoxygenase and cyclooxygenase activities. Daphnodorin B had no effect on the two enzymatic pathways. The present data raise the possibility that daphnodorin A and C can be anti-thrombotic and anti-atherosclerotic drugs through the suppressive influence on the platelet 12-lipoxygenase and cyclooxygenase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/12-Hydroxy-5,8,10,14-eicosatetraenoi...,
http://linkedlifedata.com/resource/pubmed/chemical/12-hydroxy-5,8,10-heptadecatrienoic...,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 12-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/daphnodorin A,
http://linkedlifedata.com/resource/pubmed/chemical/daphnodorin B,
http://linkedlifedata.com/resource/pubmed/chemical/daphnodorin C
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0952-3278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9578153-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid,
pubmed-meshheading:9578153-Animals,
pubmed-meshheading:9578153-Arachidonate 12-Lipoxygenase,
pubmed-meshheading:9578153-Arachidonic Acid,
pubmed-meshheading:9578153-Benzopyrans,
pubmed-meshheading:9578153-Blood Platelets,
pubmed-meshheading:9578153-Chromatography, High Pressure Liquid,
pubmed-meshheading:9578153-Dose-Response Relationship, Drug,
pubmed-meshheading:9578153-Drugs, Chinese Herbal,
pubmed-meshheading:9578153-Fatty Acids, Unsaturated,
pubmed-meshheading:9578153-Insecticides,
pubmed-meshheading:9578153-Male,
pubmed-meshheading:9578153-Medicine, Chinese Traditional,
pubmed-meshheading:9578153-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:9578153-Rabbits
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pubmed:year |
1998
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pubmed:articleTitle |
Effects of daphnodorin A, B and C, new flavans isolated from traditional Chinese medicine, on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets.
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pubmed:affiliation |
Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
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pubmed:publicationType |
Journal Article
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