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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1998-5-15
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pubmed:abstractText |
Osteochondroma most frequently arises sporadically and as a solitary lesion, but also may arise as multiple lesions characterizing the autosomal dominant disorder hereditary multiple exostoses (HME) and the contiguous gene syndromes Langer-Giedion and DEFECT-11 syndromes. HME is genetically heterogeneous with association of three loci including 8q24.1 (EXT1), 11p11-12 (EXT2), and 19p (EXT3). Constitutional chromosomal microdeletions of 8q24.1 and 11p11-12 are features of the Langer-Giedion and DEFECT-11 syndromes, respectively. Cytogenetic studies of osteochondroma are rare.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1657-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9576285-Adolescent,
pubmed-meshheading:9576285-Adult,
pubmed-meshheading:9576285-Child,
pubmed-meshheading:9576285-Chromosome Aberrations,
pubmed-meshheading:9576285-Chromosome Deletion,
pubmed-meshheading:9576285-Chromosome Disorders,
pubmed-meshheading:9576285-Chromosomes, Human, Pair 11,
pubmed-meshheading:9576285-Chromosomes, Human, Pair 8,
pubmed-meshheading:9576285-Exostoses, Multiple Hereditary,
pubmed-meshheading:9576285-Female,
pubmed-meshheading:9576285-Gene Rearrangement,
pubmed-meshheading:9576285-Humans,
pubmed-meshheading:9576285-Karyotyping,
pubmed-meshheading:9576285-Male,
pubmed-meshheading:9576285-Osteochondroma
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pubmed:year |
1998
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pubmed:articleTitle |
Clonal karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas.
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pubmed:affiliation |
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5440, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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