|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1998-6-1
|
|
pubmed:abstractText |
Human ras-GTPase-activating protein (GAP120) SH3-domain-binding protein (G3BP) has recently been identified on the basis of its specific binding to the GAP120 SH3 binding domain. Here we report the identification of a mouse G3BP cDNA and the confirmation by three dimensional modelling of an RNA recognition motif (RRM) in the encoded protein. Mouse G3BP also contains an RGG domain, an acid-rich amino acid domain, and several SH3 domain-binding consensus sequences, indicating that mammalian G3BPs represent a new family of signal transduction proteins which connect tyrosine kinase-linked receptors to cellular RNA metabolism.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoprotein, U1 Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/U1A protein,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1353-8616
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
93-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9575347-Amino Acid Sequence,
pubmed-meshheading:9575347-Animals,
pubmed-meshheading:9575347-Base Sequence,
pubmed-meshheading:9575347-Binding Sites,
pubmed-meshheading:9575347-DNA, Complementary,
pubmed-meshheading:9575347-DNA Primers,
pubmed-meshheading:9575347-GTPase-Activating Proteins,
pubmed-meshheading:9575347-Humans,
pubmed-meshheading:9575347-Mice,
pubmed-meshheading:9575347-Models, Molecular,
pubmed-meshheading:9575347-Molecular Sequence Data,
pubmed-meshheading:9575347-Polymerase Chain Reaction,
pubmed-meshheading:9575347-Protein Conformation,
pubmed-meshheading:9575347-Proteins,
pubmed-meshheading:9575347-RNA,
pubmed-meshheading:9575347-RNA-Binding Proteins,
pubmed-meshheading:9575347-Ribonucleoprotein, U1 Small Nuclear,
pubmed-meshheading:9575347-Sequence Homology, Amino Acid,
pubmed-meshheading:9575347-Signal Transduction,
pubmed-meshheading:9575347-Species Specificity,
pubmed-meshheading:9575347-ras GTPase-Activating Proteins,
pubmed-meshheading:9575347-src Homology Domains
|
|
pubmed:articleTitle |
Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif.
|
|
pubmed:affiliation |
Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
