Linked Life Data

9574675

Source:http://linkedlifedata.com/resource/pubmed/id/9574675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1998-6-9
pubmed:abstractText
Helicobacter pylori serology and in particular enzyme-linked immunosorbent assays for the measurement of immunoglobulin G (IgG) antibody titers form an accurate means of diagnosing H. pylori infection in patients before treatment. H. pylori serology is of limited value in monitoring treatment because of the slow decline in antibody titers. In the present study we aimed to measure the most suitable moment after antibiotic treatment at which serology should be used to monitor treatment. Sixty-four patients who had nonulcer dyspepsia and H. pylori infection and who underwent upper gastrointestinal endoscopy because of persistent dyspeptic symptoms were included in the study. H. pylori cure was confirmed by histology and culture 5 weeks after the completion of the antibiotic treatment. Serological examination was performed before therapy and at 5 weeks, 10 weeks, and 1 year after the completion of antibiotic treatment. Diagnostic performance was assessed by receiver-operating characteristic analysis. The areas under the receiver-operating characteristic curves of the H. pylori antibody titers at 5 weeks, 10 weeks, and 1 year after the completion of treatment were 0.53 (95% confidence interval [CI], 0.36 to 0.69), 0.60 (95% CI, 0.43 to 0.76), and 0.78 (95% CI, 0.63 to 0.93), respectively. The areas under the receiver-operating characteristic curves of the changes in H. pylori IgG antibody titers at 5 weeks, 10 weeks, and 1 year after the completion of treatment in comparison with the pretreatment titers were 0.85 (95% CI, 0.72 to 0.97), 0.96 (95% CI, 0.89 to 1.0), and 1.0 (95% CI, not estimable), respectively. We conclude that serology forms a useful means of monitoring treatment in patients with nonulcer dyspepsia and H. pylori infection as early as 10 weeks and maybe even sooner after the completion of treatment for the infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-1348298, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-1734050, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-1752457, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-2753404, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-7490184, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-8051244, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-8261831, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-8541040, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-8748281, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-8853771, http://linkedlifedata.com/resource/pubmed/commentcorrection/9574675-8971279
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1193-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Short-term follow-up by serology of patients given antibiotic treatment for Helicobacter pylori infection.
pubmed:affiliation
Department of Gastroenterology, University Hospital Nijmegen, The Netherlands. R.Laheij@mie.kun.nl
pubmed:publicationType
Journal Article