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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-6-11
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| pubmed:abstractText |
To evaluate renal tubular functions and to investigate the causative factors of urinary-concentrating defects in the late stage of hemorrhagic fever with renal syndrome (HFRS), 11 HFRS patients in the convalescent phase were studied and compared with 8 acute renal failure (ARF) patients in convalescence (disease controls) and 9 healthy adults preparing for kidney donation (normal controls, NC). Minimal urine osmolality induced by water loading was higher (p < 0.05) in HFRS (89.5 +/- 22.1 mosm/kg) and ARF patients (84.8 +/- 14.7 mosm/ kg) than in NC (47.8 +/- 4.6 mosm/kg), but the solute-free water clearance of HFRS patients (9.0 +/- 1.3%), measured at maximal diuresis, was not different from that of ARF patients (6.7 +/- 1.2%) or NC (10.5 +/- 1.4%). After 12-hour water deprivation + vasopressin stimulation, HFRS had lower urine osmolality (433.7 +/- 31.1 versus 850.0 +/- 35.1 mosm/kg; p < 0.05), urine-to-plasma osmolality ratio (1.47 +/- 0.11 versus 2.91 +/- 0.11; p < 0.05), and solute-free water reabsorption (0.53 +/- 0.07 versus 0.91 +/- 0.12%; p < 0.05) than NC. As compared with ARF patients (1.09 +/- 0.16%) or NC (1.49 +/- 0.16%), HFRS patients (0.43 +/- 0.20%) had lower solute-free water reabsorption measured at maximal antidiuresis induced by water deprivation + vasopressin stimulation + hypertonic saline infusion (p < 0.05). In HFRS, the plasma vasopressin level and plasma vasopressin/osmolality ratio increased from 3.9 +/- 0.8 to 6.1 +/- 1.1 pg/ml and from 0.013 +/- 0.003 to 0.020 +/- 0.004 pg/ml/mosm/kg after 12-hour water deprivation, respectively (p < 0.01). However, neither basal nor stimulated values of the plasma vasopressin level or plasma vasopressin/osmolality ratio was different among the 3 groups. HFRS patients were not different from ARF patients or NC in lithium clearance, urinary-acidifying capacity, and fractional excretions of sodium, potassium and bicarbonate. We conclude that in the convalescent phase of HFRS, the urinary-acidifying ability is not disturbed, the urinary-diluting defect is mild, and the urinary-concentrating capacity is obviously impaired. This study suggests that the most important factor contributing to the urinary-concentrating defect in HFRS is the reduced collecting duct responsiveness to vasopressin.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0250-8095
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
123-30
|
| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:9569954-Acute Kidney Injury,
pubmed-meshheading:9569954-Adolescent,
pubmed-meshheading:9569954-Adult,
pubmed-meshheading:9569954-Aged,
pubmed-meshheading:9569954-Biological Markers,
pubmed-meshheading:9569954-Convalescence,
pubmed-meshheading:9569954-Female,
pubmed-meshheading:9569954-Hemorrhagic Fever with Renal Syndrome,
pubmed-meshheading:9569954-Humans,
pubmed-meshheading:9569954-Hydrogen-Ion Concentration,
pubmed-meshheading:9569954-Kidney Function Tests,
pubmed-meshheading:9569954-Kidney Tubules,
pubmed-meshheading:9569954-Lithium,
pubmed-meshheading:9569954-Male,
pubmed-meshheading:9569954-Metabolic Clearance Rate,
pubmed-meshheading:9569954-Middle Aged,
pubmed-meshheading:9569954-Osmolar Concentration,
pubmed-meshheading:9569954-Urine
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Evaluation of renal tubular functions in convalescent phase of hemorrhagic fever with renal syndrome.
|
| pubmed:affiliation |
Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Korea.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|