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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-6-11
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pubmed:abstractText |
Glomerular deposition of IgA1 is a common feature of Henoch-Schönlein purpura, and is indistinguishable from that seen in IgA nephropathy. Serum IgA1 is abnormally O-glycosylated in IgA nephropathy, and this may contribute to mesangial IgA1 deposition and the development of glomerular injury. This altered O-glycosylation of IgA1 can be detected by its increased binding to the lectin Vicia villosa.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0931-0509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
930-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9568852-Adolescent,
pubmed-meshheading:9568852-Adult,
pubmed-meshheading:9568852-Aged,
pubmed-meshheading:9568852-Amino Acid Sequence,
pubmed-meshheading:9568852-Child,
pubmed-meshheading:9568852-Child, Preschool,
pubmed-meshheading:9568852-Female,
pubmed-meshheading:9568852-Glomerulonephritis, IGA,
pubmed-meshheading:9568852-Glycosylation,
pubmed-meshheading:9568852-Humans,
pubmed-meshheading:9568852-Immunoglobulin A,
pubmed-meshheading:9568852-Lectins,
pubmed-meshheading:9568852-Male,
pubmed-meshheading:9568852-Middle Aged,
pubmed-meshheading:9568852-Molecular Sequence Data,
pubmed-meshheading:9568852-Plant Lectins,
pubmed-meshheading:9568852-Purpura, Schoenlein-Henoch
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pubmed:year |
1998
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pubmed:articleTitle |
Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis.
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pubmed:affiliation |
Department of Nephrology, Leicester General Hospital, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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