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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-6-11
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pubmed:abstractText |
We examined the effect of probucol on the aortic atherosclerosis already developed in Watanabe heritable hyperlipidemic (WHHL) rabbits at the initiation of treatment. In WHHL rabbits treated with probucol for 5 months from 8 months old, the lesion area in the aorta was significantly (P < 0.05) reduced when compared with that in untreated animals as well as animals at age 8 months. In contrast, plasma cholesterol levels in the probucol-treated group and untreated group during the experiment were not significantly different. LDL prepared from rabbits receiving probucol for 5 months showed resistance to oxidation by copper ions. Plasma CETP activity was significantly (P < 0.05) increased by probucol treatment. An immunohistochemical study showed that macrophages were abundant in the atherosclerotic lesions of untreated rabbits whereas smooth muscle cells were predominant in lesions of probucol-treated rabbits. These results suggest that the atherosclerotic lesion in WHHL rabbits can regress when treated by probucol and that the attenuation of atherosclerosis in this animal involves effects of probucol other than a decrease in plasma cholesterol, for example anti-oxidant activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Ester Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Probucol
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9150
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9568732-Actins,
pubmed-meshheading:9568732-Animals,
pubmed-meshheading:9568732-Anticholesteremic Agents,
pubmed-meshheading:9568732-Aorta, Abdominal,
pubmed-meshheading:9568732-Aorta, Thoracic,
pubmed-meshheading:9568732-Aortic Diseases,
pubmed-meshheading:9568732-Arteriosclerosis,
pubmed-meshheading:9568732-Body Weight,
pubmed-meshheading:9568732-Carrier Proteins,
pubmed-meshheading:9568732-Cell Count,
pubmed-meshheading:9568732-Cholesterol,
pubmed-meshheading:9568732-Cholesterol, HDL,
pubmed-meshheading:9568732-Cholesterol, LDL,
pubmed-meshheading:9568732-Cholesterol, VLDL,
pubmed-meshheading:9568732-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:9568732-Data Interpretation, Statistical,
pubmed-meshheading:9568732-Dose-Response Relationship, Drug,
pubmed-meshheading:9568732-Energy Intake,
pubmed-meshheading:9568732-Glycoproteins,
pubmed-meshheading:9568732-Hyperlipidemias,
pubmed-meshheading:9568732-Immunohistochemistry,
pubmed-meshheading:9568732-Macrophages,
pubmed-meshheading:9568732-Muscle, Smooth,
pubmed-meshheading:9568732-Oxidation-Reduction,
pubmed-meshheading:9568732-Probucol,
pubmed-meshheading:9568732-Rabbits,
pubmed-meshheading:9568732-Subcellular Fractions,
pubmed-meshheading:9568732-Tunica Intima
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pubmed:year |
1998
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pubmed:articleTitle |
Probucol treatment attenuates the aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
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pubmed:affiliation |
Exploratory Research Laboratories II, Daiichi Pharmaceutical, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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