Linked Life Data

9566989

Source:http://linkedlifedata.com/resource/pubmed/id/9566989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1998-6-8
pubmed:abstractText
The ODS rat (genotype od/od), which has a hereditary defect in ascorbic acid biosynthesis, was used to investigate the effects of ascorbic acid deficiency on the hepatic gene expression of both the positive acute phase proteins, haptoglobin and alpha1-acid glycoprotein, and the negative acute phase proteins, apolipoprotein A-I and albumin. Male ODS rats (6 wk old, body weight approximately 140 g) were fed a basal diet containing ascorbic acid (300 mg/kg diet) or a diet without ascorbic acid for 14 d. Ascorbic acid deficiency significantly elevated the serum concentration of haptoglobin and significantly lowered those of apolipoprotein A-I and albumin. The hepatic mRNA levels of haptoglobin and alpha1-acid glycoprotein in the ascorbic acid-deficient rats were significantly elevated on d 12, and reached 260 (P < 0.05) and 360% (P < 0.01) of respective values in the control rats on d 14. On the contrary, the hepatic mRNA levels of apolipoprotein A-I and albumin in the ascorbic acid-deficient rats were lowered to 68 (P < 0.01) and 71% (P < 0.05) of respective values in the control rats on d 14. Although ascorbic acid deficiency significantly elevated the serum corticosterone concentration on d 14, the changes in mRNA levels of haptoglobin, alpha1-acid glycoprotein, apolipoprotein A-I and albumin due to ascorbic acid deficiency were not affected by adrenalectomy, as assessed in a separate experiment. The serum concentration of interleukin-6, an inflammatory cytokine that stimulates gene expression of some acute phase proteins, was significantly higher in the ascorbic acid-deficient rats on d 14 than in the control rats. These results suggest that ascorbic acid deficiency causes physiologic changes similar to those that occur in the acute phase response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
832-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9566989-Acute-Phase Proteins, pubmed-meshheading:9566989-Adrenalectomy, pubmed-meshheading:9566989-Albumins, pubmed-meshheading:9566989-Animals, pubmed-meshheading:9566989-Apolipoprotein A-I, pubmed-meshheading:9566989-Ascorbic Acid Deficiency, pubmed-meshheading:9566989-Base Sequence, pubmed-meshheading:9566989-Blotting, Northern, pubmed-meshheading:9566989-Body Weight, pubmed-meshheading:9566989-Cohort Studies, pubmed-meshheading:9566989-Corticosterone, pubmed-meshheading:9566989-Diet, pubmed-meshheading:9566989-Gene Expression Regulation, Developmental, pubmed-meshheading:9566989-Haptoglobins, pubmed-meshheading:9566989-Interleukin-6, pubmed-meshheading:9566989-Liver, pubmed-meshheading:9566989-Male, pubmed-meshheading:9566989-Organ Size, pubmed-meshheading:9566989-Orosomucoid, pubmed-meshheading:9566989-Polymerase Chain Reaction, pubmed-meshheading:9566989-RNA, Messenger, pubmed-meshheading:9566989-Rats, pubmed-meshheading:9566989-Rats, Mutant Strains, pubmed-meshheading:9566989-Time Factors
pubmed:year
1998
pubmed:articleTitle
Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats.
pubmed:affiliation
Laboratory of Nutritional Biochemistry, Department of Applied Biological Sciences, School of Agricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't