Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-5-14
|
| pubmed:abstractText |
Peripheral blood mononuclear cells (PBMC) from 117 individuals living on two islands in an area (Dongting Lake) endemic for schistosomiasis japonica in China, and 15 control individuals from a non-endemic area of China, were assessed for antigen-stimulated proliferation against five recombinant Schistosoma japonicum antigens of recognized interest in the development of immunity to schistosomiasis. Two recombinant antigens, paramyosin and 28-kD glutathione-S-transferase, stimulated cellular proliferation (stimulation index > or = 3.0) in 38.5% and 42.5% of subjects, respectively, a level similar to that induced by a soluble whole parasite extract (51.3%). In contrast, three other recombinant antigens tested--a fatty acid binding protein, 22-kD tegumental membrane-associated antigen, and glyceraldehyde-3-phosphate dehydrogenase--stimulated PBMC proliferation in only 3-8% of subjects. Moreover, we also identified a positive association between the degree of exposure, and cellular proliferation following stimulation with recombinant paramyosin or whole parasite extract. Highly significant differences in antigen-stimulated proliferation were also observed between the two islands, Niangashan and Qingshan. The whole parasite extract stimulated proliferation in 90% of subjects from Niangashan island compared with only 42.1% of subjects from Qingshan island (chi2 = 16.88, P = 0.00004), while glutathione-S-transferase stimulated proliferation in 77.3% of subjects from Niangashan island compared with only 34.7% of subjects from Qingshan island (chi2 = 13.09, P = 0.003). A similar, but not significant, trend was observed for paramyosin and the fatty-acid binding protein. The identification of differential cellular proliferative responses to specific schistosome antigens within an infected human population may have important practical implications for vaccine development against schistosomiasis japonica.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-1601036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-2493482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-3128605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-3135553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-7958962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8194761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8225573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8406870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8419165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8419485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8552619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8647218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-8926066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-9084036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-9164605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-9174407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-9223156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-9223157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9566792-9311640
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0009-9104
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
112
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
69-73
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9566792-Adult,
pubmed-meshheading:9566792-Animals,
pubmed-meshheading:9566792-Antigens, Helminth,
pubmed-meshheading:9566792-Cell Division,
pubmed-meshheading:9566792-China,
pubmed-meshheading:9566792-Female,
pubmed-meshheading:9566792-Humans,
pubmed-meshheading:9566792-Leukocytes, Mononuclear,
pubmed-meshheading:9566792-Male,
pubmed-meshheading:9566792-Recombinant Proteins,
pubmed-meshheading:9566792-Schistosoma japonicum,
pubmed-meshheading:9566792-Schistosomiasis japonica
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Differential antigen-stimulated proliferation of human mononuclear cells by recombinant Schistosoma japonicum antigens in a Chinese population.
|
| pubmed:affiliation |
Molecular Parasitology Unit, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|