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pubmed-article:9566384pubmed:abstractTextVirtually all individuals with Down syndrome (DS) have neuropathologic changes characteristic of Alzheimer's disease (AD) beginning at 40 years of age. Few studies have examined factors that influence age at onset of AD in DS. We investigated whether sex differences in age at onset and risk of AD among adults with DS are similar to those observed in the general population and whether the effect of sex on risk of AD is modified by apolipoprotein E (APOE) genotype.lld:pubmed
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pubmed-article:9566384pubmed:articleTitleEarlier onset of Alzheimer's disease in men with Down syndrome.lld:pubmed
pubmed-article:9566384pubmed:affiliationNYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.lld:pubmed
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