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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-6-26
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pubmed:abstractText |
The DNA-binding protein encoded by the zeste gene of Drosophila activates transcription and mediates interchromosomal interactions such as transvection. The mutant protein encoded by the zeste1 (z1) allele retains the ability to support transvection, but represses white. Similar to transvection, repression requires Zeste-Zeste protein interactions and a second copy of white, either on the homologous chromosome or adjacent on the same chromosome. We characterized two pseudorevertants of z1 (z1-35 and z1-42) and another zeste mutation (z78c) that represses white. The z1 lesion alters a lysine residue located between the N-terminal DNA-binding domain and the C-terminal hydrophobic repeats involved in Zeste self-interactions. The z78c mutation alters a histidine near the site of the z1 lesion. Both z1 pseudorevertants retain the z1 lesion and alter different prolines in a proline-rich region located between the z1 lesion and the self-interaction domain. The pseudorevertants retain the ability to self-interact, but fail to repress white or support transvection at Ultrabithorax. To account for these observations and evidence indicating that Zeste affects gene expression through Polycomb group (Pc-G) protein complexes that epigenetically maintain chromatin states, we suggest that the regions affected by the z1, z78c, and pseudorevertant lesions mediate interactions between Zeste and the maintenance complexes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-1353445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-1644294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-1732733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-1763708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2118108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2121595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2162766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2341036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2505416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2511424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-2981631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3004962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3004963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3125410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3127690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3131017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3145199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3431465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3582372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3608982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-3868483,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-7580138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-7613086,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-7662368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-7896099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-7916186,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8467801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8491196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8536972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8585123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8657287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8725236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-8763830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9560400-9115424
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proline,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Ubx protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/white protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/z protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1865-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9560400-ATP-Binding Cassette Transporters,
pubmed-meshheading:9560400-Alleles,
pubmed-meshheading:9560400-Animals,
pubmed-meshheading:9560400-DNA-Binding Proteins,
pubmed-meshheading:9560400-Drosophila Proteins,
pubmed-meshheading:9560400-Drosophila melanogaster,
pubmed-meshheading:9560400-Eye Proteins,
pubmed-meshheading:9560400-Female,
pubmed-meshheading:9560400-Gene Expression Regulation,
pubmed-meshheading:9560400-Homeodomain Proteins,
pubmed-meshheading:9560400-Insect Proteins,
pubmed-meshheading:9560400-Male,
pubmed-meshheading:9560400-Mutagenesis,
pubmed-meshheading:9560400-Phenotype,
pubmed-meshheading:9560400-Proline,
pubmed-meshheading:9560400-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
A proline-rich region in the Zeste protein essential for transvection and white repression by Zeste.
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pubmed:affiliation |
Program in Molecular Biology, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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