| pubmed-article:9559930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9559930 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9559930 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:9559930 | lifeskim:mentions | umls-concept:C0813872 | lld:lifeskim |
| pubmed-article:9559930 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9559930 | pubmed:dateCreated | 1998-6-2 | lld:pubmed |
| pubmed-article:9559930 | pubmed:abstractText | We evaluated the incentive motivational properties of MK-801 by determining its priming effect on drug-seeking behaviour following extinction of cocaine self-administration, an animal model for drug craving. Rats were allowed to self-administrate cocaine (0.5 mg/kg) or saline during 10 daily sessions. MK-801 (0.1-0.25 mg/kg, i.p.) dose-dependently reinstated responding for cocaine following an extinction period of 3 weeks. Responding was selectively enhanced in the previously drug-paired hole and was completely absent in rats with a history of saline self-administration. These data provide evidence for a possible role of NMDA receptors in the incentive motivation underlying cocaine-seeking behaviour. In addition, the ability of MK-801 to elicit drug-seeking behaviour may prove to be a serious drawback for the proposed use of NMDA antagonists in the treatment of drug addiction. | lld:pubmed |
| pubmed-article:9559930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9559930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9559930 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9559930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9559930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9559930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9559930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9559930 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9559930 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:9559930 | pubmed:author | pubmed-author:MulderA HAH | lld:pubmed |
| pubmed-article:9559930 | pubmed:author | pubmed-author:BinnekadeRR | lld:pubmed |
| pubmed-article:9559930 | pubmed:author | pubmed-author:SchoffelmeerA... | lld:pubmed |
| pubmed-article:9559930 | pubmed:author | pubmed-author:De VriesT JTJ | lld:pubmed |
| pubmed-article:9559930 | pubmed:author | pubmed-author:Vanderschuren... | lld:pubmed |
| pubmed-article:9559930 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9559930 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:9559930 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9559930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9559930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9559930 | pubmed:pagination | 637-40 | lld:pubmed |
| pubmed-article:9559930 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:meshHeading | pubmed-meshheading:9559930-... | lld:pubmed |
| pubmed-article:9559930 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9559930 | pubmed:articleTitle | MK-801 reinstates drug-seeking behaviour in cocaine-trained rats. | lld:pubmed |
| pubmed-article:9559930 | pubmed:affiliation | Research Institute of Neurosciences Vrije Universiteit, Department of Pharmacology, Free University, Medical Facility, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:9559930 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9559930 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9559930 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9559930 | lld:pubmed |
