|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1998-4-30
|
|
pubmed:abstractText |
The present study was designed to determine the frequency of germline mutations in the hMLH1 and hMSH2 genes in 31 families suspected of having hereditary nonpolyposis colorectal cancer who do not fulfill the criteria of the International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer but in whom a genetic basis for colon cancer is strongly suspected and 45 patients with sporadic early-onset colorectal cancer who developed colorectal cancer before the age of 40 years without any family history of colorectal cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0012-3706
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
41
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
434-40
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9559627-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9559627-Adult,
pubmed-meshheading:9559627-Aged,
pubmed-meshheading:9559627-Carrier Proteins,
pubmed-meshheading:9559627-Colorectal Neoplasms,
pubmed-meshheading:9559627-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:9559627-DNA Repair,
pubmed-meshheading:9559627-DNA-Binding Proteins,
pubmed-meshheading:9559627-Female,
pubmed-meshheading:9559627-Frameshift Mutation,
pubmed-meshheading:9559627-Gene Deletion,
pubmed-meshheading:9559627-Germ-Line Mutation,
pubmed-meshheading:9559627-Humans,
pubmed-meshheading:9559627-Male,
pubmed-meshheading:9559627-Middle Aged,
pubmed-meshheading:9559627-MutS Homolog 2 Protein,
pubmed-meshheading:9559627-Neoplasm Proteins,
pubmed-meshheading:9559627-Nuclear Proteins,
pubmed-meshheading:9559627-Point Mutation,
pubmed-meshheading:9559627-Proto-Oncogene Proteins,
pubmed-meshheading:9559627-Statistics as Topic
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer.
|
|
pubmed:affiliation |
Laboratory of Cell Biology, Cancer Research Center, Seoul National University College of Medicine, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
