Linked Life Data

9557973

Source:http://linkedlifedata.com/resource/pubmed/id/9557973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-7-23
pubmed:abstractText
The objective of the present study was to provide direct evidence regarding GABAergic projections from the nuclei of the lateral lemniscus to the central nucleus of the inferior colliculus (ICC), and from the ICC to the opposite ICC. Projections of GABAergic neurons in the rat were investigated by a combination of fluorogold (FG) retrograde tracing and GABA immunocytochemistry. FG was first injected into a frequency-defined region (11-13 kHz) in the center of the ICC, and 1-2 weeks was allowed for retrograde transport. Vibratome sections were then cut through the brainstem and stained with GABA antibody. Double-labeling was taken as evidence of GABAergic neurons projecting to the ICC. The results from FG retrograde labeling alone showed that neurons in the dorsal nucleus of the lateral lemniscus (DNLL) bilaterally, in the intermediate and ventral nucleus of the lateral lemniscus (INLL and VNLL) ipsilaterally, and in the ICC contralaterally project to the ICC. GABA immunostaining alone showed substantial numbers of GABA positive neurons in the nuclei of the lateral lemniscus and the inferior colliculus. FG and GABA double-labeled neurons were present in all nuclei of the lateral lemniscus that project to the ICC. The greatest concentration of double-labeled neurons was found bilaterally in the DNLL, suggesting a prominent GABAergic projection from the DNLL to the ICC. The presence of many double-labeled neurons in the ipsilateral INLL and VNLL suggests that there are also GABAergic inputs from the INLL and VNLL to the ICC. No double-labeled neurons were found in the contralateral ICC, which suggests the possibility of a prominent non-GABAergic projection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0378-5955
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-12
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
GABAergic projections from the lateral lemniscus to the inferior colliculus of the rat.
pubmed:affiliation
Department of Psychology, Carleton University, Ottawa, Ont, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't