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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-5-20
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pubmed:abstractText |
We have investigated the mechanisms involved in the clearance of viral infection at the epithelium level by analyzing the activity of influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live influenza virus effectively present viral antigens and were lysed by both homotypic and heterotypic influenza virus-specific CD8+ T cells. These results shed new light on the control of viral infection through the elimination of virus-infected epithelial cells by virus-specific CTL and demonstrate that CMT-93 cells furnish an appropriate model for in vitro evaluation of CTL activity against virus-infected epithelial cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-2196043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-2426185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-3041033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-306410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-3493324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-358960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-3872457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-4060851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6148853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6159417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6184304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6267157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6273293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6602294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-6972261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-7191866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-7253097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-7512524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-7843219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-7875747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-8230464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-9094677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557755-9225046
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4534-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9557755-Animals,
pubmed-meshheading:9557755-Antigens, Viral,
pubmed-meshheading:9557755-Epithelial Cells,
pubmed-meshheading:9557755-Guinea Pigs,
pubmed-meshheading:9557755-Humans,
pubmed-meshheading:9557755-Influenza A virus,
pubmed-meshheading:9557755-Mice,
pubmed-meshheading:9557755-Mice, Inbred C57BL,
pubmed-meshheading:9557755-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9557755-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes.
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pubmed:affiliation |
Department of Microbiology and The Immunobiology Vaccine Center, University of Alabama at Birmingham, 35294-2170, USA. nghuan@uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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