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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-5-20
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pubmed:abstractText |
Pit1 is the human receptor for gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B), while the related human protein Pit2 is a receptor for amphotropic murine leukemia virus (A-MuLV). The A-MuLV-related isolate 10A1 can utilize both Pit1 and Pit2 as receptors. A stretch of amino acids named region A was identified in Pit1 (residues 550 to 558 in loop 4) as critical for GALV and FeLV-B receptor function. We have here investigated the role of region A in A-MuLV and 10A1 entry. Insertion of a single amino acid in region A of mouse Pit1 resulted in a functional A-MuLV receptor, showing that region A plays a role in A-MuLV infection. Moreover, the downregulation of 10A1 receptor function by changes in region A of human Pit1 indicates that this region is also involved in 10A1 entry. Therefore, region A seems to play a role in infection by all viruses utilizing Pit1 and/or Pit2 as receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-1309898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-1310758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-1321266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-1326661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-1531369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-1651417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-2078500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-2631796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-3600789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-7884886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-7929240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-7966559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-7966619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-7983751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8041748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8046392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8278411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8302848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8391178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8411375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8411376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8551566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-8794342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-9032341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-9151850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-9287219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-9311843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9557753-9311908
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4524-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9557753-3T3 Cells,
pubmed-meshheading:9557753-Animals,
pubmed-meshheading:9557753-CHO Cells,
pubmed-meshheading:9557753-Cricetinae,
pubmed-meshheading:9557753-Humans,
pubmed-meshheading:9557753-Leukemia Virus, Murine,
pubmed-meshheading:9557753-Mice,
pubmed-meshheading:9557753-Mutagenesis, Insertional,
pubmed-meshheading:9557753-Receptors, Virus,
pubmed-meshheading:9557753-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
Single amino acid insertion in loop 4 confers amphotropic murine leukemia virus receptor function upon murine Pit1.
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pubmed:affiliation |
Department of Molecular and Structural Biology, University of Aarhus, Aarhus C, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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