|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0027950,
umls-concept:C0030306,
umls-concept:C0030685,
umls-concept:C0036085,
umls-concept:C0086418,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1515877,
umls-concept:C1879547,
umls-concept:C1963578,
umls-concept:C2349975
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1998-5-1
|
|
pubmed:abstractText |
Ongoing clinical trials have revived interest in hypertonic saline (HTS) for postinjury resuscitation; these studies have documented serum Na+ concentrations > or = 170 mmol/L. Recent animal studies have shown that HTS enhances T-cell and monocyte function, but effects on the polymorphonuclear neutrophil (PMN) remain unclear. The postinjury lipid mediators platelet-activating factor (PAF) and leukotriene B4 (LTB4) have been implicated in PMN priming for cytotoxicity, which is believed to be important in the pathogenesis of multiple organ failure. We hypothesized that HTS would stimulate PMN superoxide (O2-) and elastase release from PAF- and LTB4-primed PMNs.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0022-5282
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
592-7; discussion 598
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9555828-Humans,
pubmed-meshheading:9555828-Leukotriene B4,
pubmed-meshheading:9555828-Multiple Organ Failure,
pubmed-meshheading:9555828-Multiple Trauma,
pubmed-meshheading:9555828-Neutrophil Activation,
pubmed-meshheading:9555828-Neutrophils,
pubmed-meshheading:9555828-Osmolar Concentration,
pubmed-meshheading:9555828-Pancreatic Elastase,
pubmed-meshheading:9555828-Platelet Activating Factor,
pubmed-meshheading:9555828-Resuscitation,
pubmed-meshheading:9555828-Saline Solution, Hypertonic,
pubmed-meshheading:9555828-Superoxides
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release.
|
|
pubmed:affiliation |
Department of Surgery, Denver Health Medical Center, Colorado 80204, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
