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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-4-29
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pubmed:abstractText |
p16 (MTS 1) and p15 (MTS 2) are negative regulators of cell cycle progression at the G1 cell cycle checkpoint and function as tumor suppressor genes (TSG). Both p15 and p16 are located on chromosome 9p21 and alterations have been demonstrated in a variety of human malignancies and human cancer cell lines. In testicular germ cell tumors (TGCT) loss of heterozygosity of 9p21 to 23 has been observed in 41% to 72% of informative cases. The aim of our study was to examine TGCT and testicular cancer cell lines for deletions and mutations of the p15 and p16 genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1725-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9554401-Blotting, Southern,
pubmed-meshheading:9554401-Carrier Proteins,
pubmed-meshheading:9554401-Cell Cycle Proteins,
pubmed-meshheading:9554401-Chromosomes, Human, Pair 9,
pubmed-meshheading:9554401-Cyclin-Dependent Kinase Inhibitor p15,
pubmed-meshheading:9554401-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:9554401-Gene Deletion,
pubmed-meshheading:9554401-Genes, Tumor Suppressor,
pubmed-meshheading:9554401-Genes, p16,
pubmed-meshheading:9554401-Germinoma,
pubmed-meshheading:9554401-Humans,
pubmed-meshheading:9554401-Loss of Heterozygosity,
pubmed-meshheading:9554401-Male,
pubmed-meshheading:9554401-Methylation,
pubmed-meshheading:9554401-Polymerase Chain Reaction,
pubmed-meshheading:9554401-Promoter Regions, Genetic,
pubmed-meshheading:9554401-Testicular Neoplasms,
pubmed-meshheading:9554401-Transcription, Genetic,
pubmed-meshheading:9554401-Tumor Cells, Cultured,
pubmed-meshheading:9554401-Tumor Suppressor Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors.
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pubmed:affiliation |
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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