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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1998-5-13
|
| pubmed:abstractText |
c-myc has emerged as one of the central regulators of mammalian cell proliferation. The gene encodes a transcription factor of the HLH/leucine zipper family of proteins that activates transcription as part of a heteromeric complex with a protein termed Max. In mammalian fibroblasts, Myc acts as an upstream regulator of cyclin-dependent kinases and functionally antagonises the action of at least one cdk inhibitor, p27. Myc also induces cells to undergo apoptosis, and the relationship between Myc-induced cell cycle entry and apoptosis is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1087-2957
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
73-82
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9552384-Animals,
pubmed-meshheading:9552384-Apoptosis,
pubmed-meshheading:9552384-Cell Cycle,
pubmed-meshheading:9552384-Cell Division,
pubmed-meshheading:9552384-Cyclin-Dependent Kinases,
pubmed-meshheading:9552384-Cyclins,
pubmed-meshheading:9552384-Enzyme Activation,
pubmed-meshheading:9552384-Genes, myc,
pubmed-meshheading:9552384-Humans,
pubmed-meshheading:9552384-Models, Biological,
pubmed-meshheading:9552384-Proto-Oncogene Proteins c-myc
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
The functions of Myc in cell cycle progression and apoptosis.
|
| pubmed:affiliation |
Zentrum für Molekulare Biologie Heidelberg (ZMBH).
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|