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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-6-15
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pubmed:databankReference | |
pubmed:abstractText |
Here we report on the molecular characterization of the first molluscan NOS in the CNS of the pond snail Lymnaea stagnalis. This Lymnaea NOS (Lym-nNOS) which is expressed preferentially in the CNS is most similar to mammalian neuronal NOS but contains tandem repeats of a seven amino acid motif not found in any other known NOS. We have localized Lym-nNOS to the serotonergic cerebral giant cells (CGCs) which modulate synaptic transmission within a neural network that generates feeding behavior. Our results suggest that the CGCs employ both NO and serotonin in the modulation of the central neural network underlying feeding.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3034
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9552167-Amino Acid Sequence,
pubmed-meshheading:9552167-Animals,
pubmed-meshheading:9552167-Aplysia,
pubmed-meshheading:9552167-Base Sequence,
pubmed-meshheading:9552167-Calcium,
pubmed-meshheading:9552167-Cell Size,
pubmed-meshheading:9552167-Central Nervous System,
pubmed-meshheading:9552167-Cloning, Molecular,
pubmed-meshheading:9552167-Lymnaea,
pubmed-meshheading:9552167-Molecular Sequence Data,
pubmed-meshheading:9552167-Neurons,
pubmed-meshheading:9552167-Nitric Oxide Synthase,
pubmed-meshheading:9552167-RNA, Messenger,
pubmed-meshheading:9552167-Tissue Distribution
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pubmed:year |
1998
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pubmed:articleTitle |
Molecular characterization of NOS in a mollusc: expression in a giant modulatory neuron.
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pubmed:affiliation |
Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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