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rdf:type |
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lifeskim:mentions |
umls-concept:C0007586,
umls-concept:C0007589,
umls-concept:C0007634,
umls-concept:C0026249,
umls-concept:C0169665,
umls-concept:C0183941,
umls-concept:C0237477,
umls-concept:C0871261,
umls-concept:C1332737,
umls-concept:C1511938,
umls-concept:C1548602,
umls-concept:C1704632,
umls-concept:C1705119,
umls-concept:C1705523,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
8
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pubmed:dateCreated |
1998-5-26
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pubmed:abstractText |
In many vertebrate cell lineages, precursor cells divide a limited number of times before they arrest and terminally differentiate into postmitotic cells. It is not known what causes them to stop dividing. We have been studying the 'stopping' mechanism in the proliferating precursor cells that give rise to oligodendrocytes, the cells that make myelin in the central nervous system. We showed previously that the cyclin-dependent kinase inhibitor p27Kip1 (p27) progressively accumulates in cultured precursor cells as they proliferate and that the time course of the increase is consistent with the possibility that p27 accumulation is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation at the appropriate time.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/chondroitin sulfate proteoglycan 4
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
431-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9550698-Animals,
pubmed-meshheading:9550698-Antigens,
pubmed-meshheading:9550698-Biological Clocks,
pubmed-meshheading:9550698-Cell Cycle,
pubmed-meshheading:9550698-Cell Cycle Proteins,
pubmed-meshheading:9550698-Cell Differentiation,
pubmed-meshheading:9550698-Cell Division,
pubmed-meshheading:9550698-Cell Lineage,
pubmed-meshheading:9550698-Cells, Cultured,
pubmed-meshheading:9550698-Clone Cells,
pubmed-meshheading:9550698-Crosses, Genetic,
pubmed-meshheading:9550698-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:9550698-Genotype,
pubmed-meshheading:9550698-Mice,
pubmed-meshheading:9550698-Mice, Mutant Strains,
pubmed-meshheading:9550698-Microtubule-Associated Proteins,
pubmed-meshheading:9550698-Mitogens,
pubmed-meshheading:9550698-Oligodendroglia,
pubmed-meshheading:9550698-Optic Nerve,
pubmed-meshheading:9550698-Platelet-Derived Growth Factor,
pubmed-meshheading:9550698-Proteoglycans,
pubmed-meshheading:9550698-Thyroid Hormones,
pubmed-meshheading:9550698-Tumor Suppressor Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.
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pubmed:affiliation |
Medical Research Council Developmental Neurobiology Programme, MRC Laboratory for Molecular Cell Biology, Biology Department, University College London, London, WC1E 6BT, UK. bdurand@bcm.tmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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