| pubmed-article:9550399 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C0382839 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1523873 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1416682 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:9550399 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:9550399 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9550399 | pubmed:dateCreated | 1998-4-23 | lld:pubmed |
| pubmed-article:9550399 | pubmed:abstractText | Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules. The anti-CD94 mAb inhibits 1) the Vgamma9Vdelta2 T cell proliferation in response mycobacterial phosphoantigens and 2) the HIV-induced Vgamma9Vdelta2 T cell expansion. Vgamma9Vdelta2 T cells stimulated with nonpeptidic mycobacterial antigens produce IFN-gamma and TNF-alpha. Signaling through the CD94/NKG2 receptor interferes with the synthesis of these cytokines. The CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells. The Vgamma9Vdelta2 T cell regulation through the CD94 receptor may be important for the potentially dual function in innate immunity, i.e., 1) NK-like and 2) TCR ligand-induced cytolytic activities. | lld:pubmed |
| pubmed-article:9550399 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9550399 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9550399 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9550399 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9550399 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9550399 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:ColizziVV | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:GougeonM LML | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:López-BotetMM | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:PocciaFF | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:FourniéJ JJJ | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:BattistiniLL | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:VendettiSS | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:PoquetYY | lld:pubmed |
| pubmed-article:9550399 | pubmed:author | pubmed-author:CiprianiBB | lld:pubmed |
| pubmed-article:9550399 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9550399 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9550399 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:9550399 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9550399 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9550399 | pubmed:pagination | 6009-17 | lld:pubmed |
| pubmed-article:9550399 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9550399 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9550399 | pubmed:articleTitle | CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes. | lld:pubmed |
| pubmed-article:9550399 | pubmed:affiliation | Department of Biology, University of Rome Tor Vergata, Italy. poccia@utovrm.it | lld:pubmed |
| pubmed-article:9550399 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9550399 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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